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Characterization of action control networks in genetically determined parkinsonism (C05)

Subject Area Clinical Neurology; Neurosurgery and Neuroradiology
Term from 2011 to 2023
Project identifier Deutsche Forschungsgemeinschaft (DFG) - Project number 178316478
 
In the first two funding periods, we found evidence for increased activity of action selection networks in patients with genetically undefined parkinsonism, Parkin- and PINK1-associated parkinsonism, L-dopa-responsive dystonia, and X-linked dystonia parkinsonism. We now focus on network-related processes leading to disease manifestation by comparing asymptomatic mutation carriers with symptomatic patients with Parkin- and PINK1-associated parkinsonism, X-linked dystonia parkinsonism, and GBA-associated parkinsonism. To this end, we will use behavioral tasks, EEG, TMS, pupillometry, and neuromelanin-sensitive high-resolution MRI.
DFG Programme Collaborative Research Centres
Applicant Institution Universität Hamburg
 
 

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