Pharmacological and electrical modulation of disturbed networks in schizophrenia and the clinical high-risk state for psychosis (C06)

• Subject Area: Biological Psychiatry
• Term: from 2011 to 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 178316478

This project aims to investigate the effects of both pharmacological modulation and transcranial AC stimulation (tACS) on alterations of connectivity patterns in different stages of schizophrenia and in the ketamine model of schizophrenia using EEG and simultaneous EEG and fMRI. Theta-tACS will target disturbed patterns of functional brain connectivity within a working-memory network related to schizophrenia cognitive symptoms. The glutamatergic intervention at the NMDA-receptor using glycine will be used to modulate alterations of (1) the gamma-band connectivity between auditory cortices related to the occurrence of auditory hallucinations and (2) a gamma-band-specific network involved in deficits in attentional auditory information processing.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 936: Multi-Site Communication in the Brain
• Applicant Institution: Universität Hamburg
• Project Heads: Privatdozent Dr. Gregor Leicht, since 7/2019; Professor Dr. Christoph Mulert