Project Details
Projekt
The contribution of mechanisms of aging of HSCs to leukemia initiation and progression (A01)
Subject Area
Hematology, Oncology
Term
from 2012 to 2024
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 217328187
Myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) are diseases of the elderly. MDS or AML might be, based on our novel hypothesis, diseases in which expansion/selection of the fittest (but differentiation impaired) hematopoietic stem-cell (HSC) clone (like a p53-/- HSC) is at least in part driven by molecular changes that cause aging of HSCs. We will test whether pharmacological approaches that attenuate aging of HSCs might be novel approaches to alleviate initiation and/or progression of MDS or AML.
DFG Programme
Collaborative Research Centres
Applicant Institution
Universität Ulm
Project Head
Professor Dr. Hartmut Geiger, since 7/2020
