Project Details
Projekt
TIRF Mikroskopiesystem
Subject Area
Basic Research in Biology and Medicine
Term
Funded in 2012
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 223638783
Final Report Year
2016
Final Report Abstract
The TIRF/FRAP system has been essential for the successful development of the following projects: Demonstration of the impact of GAR22beta on the regulation of focal adhesion dynamics and directional cell motility. Demonstration of the essential role of the LSP1-mysoin1e bimolecular complex in the regulation of Fcgamma receptor-mediated phagocytosis. Characterization of the impact of surface topography on the differentiation and motility of mesenchymal stem cells. Characterization of the role of SigR1 receptor in the development of autophagy and lipid raft disturbancies in ALS pathology.
Publications
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2014). Loss of function of the ALS protein SigR1 leads to ER pathology associated with defective autophagy and lipid raft disturbances. Cell Death Dis 5, e1290
Vollrath, J.T., Sechi, A., Dreser, A., Katona, I., Wiemuth, D., Vervoorts, J., Dohmen, M., Chandrasekar, A., Prause, J., Brauers, E., Jesse, C.M., Weis, J., and Goswami, A.
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(2015). Crucial role for the LSP1- myosin1e bimolecular complex in the regulation of Fcgamma receptor-driven phagocytosis. Mol Biol Cell 26, 1652-1664
Maxeiner, S., Shi, N., Schalla, C., Aydin, G., Hoss, M., Vogel, S., Zenke, M., and Sechi, A.S.
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(2015). Surface topography enhances differentiation of mesenchymal stem cells towards osteogenic and adipogenic lineages. Biomaterials 61, 316-326
Abagnale, G., Steger, M., Nguyen, V.H., Hersch, N., Sechi, A., Joussen, S., Denecke, B., Merkel, R., Hoffmann, B., Dreser, A., Schnakenberg, U., Gillner, A., and Wagner, W.
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(2016). GAR22beta regulates cell migration, sperm motility, and axoneme structure. Mol Biol Cell 27, 277-294
Gamper, I., Fleck, D., Barlin, M., Spehr, M., Sayad, S.E., Kleine, H., Maxeiner, S., Schalla, C., Aydin, G., Hoss, M., Litchfield, D.W., Luscher, B., Zenke, M., and Sechi, A.
