Die Rolle von miRNAs und langen nicht-kodierenden RNAs in der Entwicklung von braunem Fettgewebe.

• Antragsteller: Dr. Marko Knoll
• Fachliche Zuordnung: Entwicklungsbiologie
• Förderung: Förderung von 2013 bis 2016
• Projektkennung: Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 235661898

• Erstellungsjahr: 2017

Zusammenfassung der Projektergebnisse

In summary, this study reveals an unexpectedly critical role for the immune kinase Syk in brown adipocyte differentiation, activation and function. A better understanding of the regulation of Syk activity and its targets in brown fat thus has the potential to reveal novel avenues towards the treatment of diabetes.

Projektbezogene Publikationen (Auswahl)

• (2017) SYK kinase mediates brown fat differentiation and activation. Nature communications 8 (1) 2115
  Knoll, Marko; Winther, Sally; Natarajan, Anirudh; Yang, Huan; Jiang, Mengxi; Thiru, Prathapan; Shahsafaei, Aliakbar; Chavarria, Tony E.; Lamming, Dudley W.; Sun, Lei; Hansen, Jacob B.; Lodish, Harvey F.
  (Siehe online unter https://doi.org/10.1038/s41467-017-02162-3)
• (2017) The Super-Enhancer-Derived alncRNA-EC7/Bloodlinc Potentiates Red Blood Cell Development in trans. Cell reports 19 (12) 2503–2514
  Alvarez-Dominguez, Juan R.; Knoll, Marko; Gromatzky, Austin A.; Lodish, Harvey F.
  (Siehe online unter https://doi.org/10.1016/j.celrep.2017.05.082)
• (2015) A respiratory chain controlled signal transduction cascade in the mitochondrial intermembrane space mediates hydrogen peroxide signaling. Proc Natl Acad Sci USA. 2015 Oct 5
  Patterson HC., Gerbeth C., Thiru P., Vögtle N.F., Knoll, M., Shahsafaei A., Samocha K.E., Huang C.X., Harden M.M., Song R., Chen C., Kao J., Shi J., Salmon W., Shaul Y.D., Stokes M.P., Silva J.C., Bell G.W., MacArthur D.G., Ruland J., Meisinger C., Lodish H.F.
  (Siehe online unter https://doi.org/10.1073/pnas.1517932112)
• (2015). De novo reconstruction of adipose tissue transcriptomes reveals long non-coding RNA regulators of brown adipocyte development. Cell Metab. 2015 May 5;21(5):764-76
  Alvarez-Dominguez, J.R., Bai, Z., Xu, D., Yuan, B., Alice Lo, K., Yoon, M.J., Lim, Y.C., Knoll, M., Slavov, N., Chen, S., Peng, C., Lodish, H.F. and Sun, L.
  (Siehe online unter https://doi.org/10.1016/j.cmet.2015.04.003)
• (2015). Long non-coding RNAs as regulators of the endocrine system. Nat Rev Endocrinol 11, 151-160
  Knoll, M., Lodish, H.F. and Sun, L.
  (Siehe online unter https://doi.org/10.1038/nrendo.2014.229)