Die Rolle von miRNAs und langen nicht-kodierenden RNAs in der Entwicklung von braunem Fettgewebe.

• Antragsteller: Dr. Marko Knoll
• Fachliche Zuordnung: Entwicklungsbiologie
• Förderung: Förderung von 2013 bis 2016
• Projektkennung: Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 235661898

• Erstellungsjahr: 2017

Zusammenfassung der Projektergebnisse

In summary, this study reveals an unexpectedly critical role for the immune kinase Syk in brown adipocyte differentiation, activation and function. A better understanding of the regulation of Syk activity and its targets in brown fat thus has the potential to reveal novel avenues towards the treatment of diabetes.

Projektbezogene Publikationen (Auswahl)

• (2015) A respiratory chain controlled signal transduction cascade in the mitochondrial intermembrane space mediates hydrogen peroxide signaling. Proc Natl Acad Sci USA. 2015 Oct 5
  Patterson, Heide Christine; Gerbeth, Carolin; Thiru, Prathapan; Vögtle, Nora F.; Knoll, Marko; Shahsafaei, Aliakbar; Samocha, Kaitlin E.; Huang, Cher X.; Harden, Mark Michael; Song, Rui; Chen, Cynthia; Kao, Jennifer; Shi, Jiahai; Salmon, Wendy; Shaul, Yoav D.; Stokes, Matthew P.; Silva, Jeffrey C.; Bell, George W.; MacArthur, Daniel G.; ... & Lodish, Harvey F.
  
• (2015). De novo reconstruction of adipose tissue transcriptomes reveals long non-coding RNA regulators of brown adipocyte development. Cell Metab. 2015 May 5;21(5):764-76
  Alvarez-Dominguez, Juan R.; Bai, Zhiqiang; Xu, Dan; Yuan, Bingbing; Lo, Kinyui Alice; Yoon, Myeong Jin; Lim, Yen Ching; Knoll, Marko; Slavov, Nikolai; Chen, Shuai; Chen, Peng; Lodish, Harvey F. & Sun, Lei
  
• (2015). Long non-coding RNAs as regulators of the endocrine system. Nat Rev Endocrinol 11, 151-160
  Knoll, Marko; Lodish, Harvey F. & Sun, Lei
  
• (2017) SYK kinase mediates brown fat differentiation and activation. Nature communications 8 (1) 2115
  Knoll, Marko; Winther, Sally; Natarajan, Anirudh; Yang, Huan; Jiang, Mengxi; Thiru, Prathapan; Shahsafaei, Aliakbar; Chavarria, Tony E.; Lamming, Dudley W.; Sun, Lei; Hansen, Jacob B. & Lodish, Harvey F.
  
• (2017) The Super-Enhancer-Derived alncRNA-EC7/Bloodlinc Potentiates Red Blood Cell Development in trans. Cell reports 19 (12) 2503–2514
  Alvarez-Dominguez, Juan R.; Knoll, Marko; Gromatzky, Austin A. & Lodish, Harvey F.