The role of miRNAs and long-noncoding (lnc) RNAs in brown adipose tissue (BAT) development.

• Applicant: Dr. Marko Knoll
• Subject Area: Developmental Biology
• Term: from 2013 to 2016
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 235661898

• Final Report Year: 2017

Final Report Abstract

In summary, this study reveals an unexpectedly critical role for the immune kinase Syk in brown adipocyte differentiation, activation and function. A better understanding of the regulation of Syk activity and its targets in brown fat thus has the potential to reveal novel avenues towards the treatment of diabetes.

Publications

• (2017) SYK kinase mediates brown fat differentiation and activation. Nature communications 8 (1) 2115
  Knoll, Marko; Winther, Sally; Natarajan, Anirudh; Yang, Huan; Jiang, Mengxi; Thiru, Prathapan; Shahsafaei, Aliakbar; Chavarria, Tony E.; Lamming, Dudley W.; Sun, Lei; Hansen, Jacob B.; Lodish, Harvey F.
  (See online at https://doi.org/10.1038/s41467-017-02162-3)
• (2017) The Super-Enhancer-Derived alncRNA-EC7/Bloodlinc Potentiates Red Blood Cell Development in trans. Cell reports 19 (12) 2503–2514
  Alvarez-Dominguez, Juan R.; Knoll, Marko; Gromatzky, Austin A.; Lodish, Harvey F.
  (See online at https://doi.org/10.1016/j.celrep.2017.05.082)
• (2015) A respiratory chain controlled signal transduction cascade in the mitochondrial intermembrane space mediates hydrogen peroxide signaling. Proc Natl Acad Sci USA. 2015 Oct 5
  Patterson HC., Gerbeth C., Thiru P., Vögtle N.F., Knoll, M., Shahsafaei A., Samocha K.E., Huang C.X., Harden M.M., Song R., Chen C., Kao J., Shi J., Salmon W., Shaul Y.D., Stokes M.P., Silva J.C., Bell G.W., MacArthur D.G., Ruland J., Meisinger C., Lodish H.F.
  (See online at https://doi.org/10.1073/pnas.1517932112)
• (2015). De novo reconstruction of adipose tissue transcriptomes reveals long non-coding RNA regulators of brown adipocyte development. Cell Metab. 2015 May 5;21(5):764-76
  Alvarez-Dominguez, J.R., Bai, Z., Xu, D., Yuan, B., Alice Lo, K., Yoon, M.J., Lim, Y.C., Knoll, M., Slavov, N., Chen, S., Peng, C., Lodish, H.F. and Sun, L.
  (See online at https://doi.org/10.1016/j.cmet.2015.04.003)
• (2015). Long non-coding RNAs as regulators of the endocrine system. Nat Rev Endocrinol 11, 151-160
  Knoll, M., Lodish, H.F. and Sun, L.
  (See online at https://doi.org/10.1038/nrendo.2014.229)