Imaging of tumor pH and metabolism using hyperpolarized 13C-labelled biosensors and simultaneous PET/MRI (A07)

• Subject Area: Medical Physics, Biomedical Technology
• Term: from 2013 to 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 68647618

The acidic tumor microenvironment has been linked to tumor progression, increased invasion and resistance to therapy and therefore shows direct relevance as a marker for cancer therapy. An extracellular pH imaging technique could effectively complement existing non-invasive imaging techniques in the clinic for a better and more accurate non-invasive assessment of tumor biology. The goal of this project is to advance current methods for non-invasive pH imaging and to demonstrate the relevance of pH imaging in combination with PET/MRI for tumor therapy using hyperpolarized 13C-labelled biosensors.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 824: Imaging for Selection, Monitoring and Individualisation of Cancer Therapies
• Applicant Institution: Technische Universität München (TUM)
• Project Heads: Professor Dr. Axel Haase; Professor Dr. Franz Schilling