Polymer-mediated tumor immunotherapy via in situ activation of antigen-presenting cells (B04)

• Subject Area: Dermatology
• Term: since 2013
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 213555243

Multifunctional nanoparticles equipped with tumor antigens and immunostimulatory TLR-agonists, as well as targeting units for addressing antigen-presenting cells (APC), can trigger an effective immune response against established murine tumors after systemic application. For this purpose, this subproject will establish biodegradable, poly(carbonate-)-based nanogels and characterize their immunotherapeutic efficacy in in-jected, metastatic and inducible melanoma models. Beyond the relevance of different APC populations and immune effector cells, the role of B-cells for tumor vaccine responses will be deciphered in detail.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1066: Nano-Dimensional Polymer Therapeutics for Tumour Therapy
• Applicant Institution: Johannes Gutenberg-Universität Mainz
• Project Heads: Professor Dr. Stephan Grabbe; Professor Dr. Lutz Nuhn; Professor Dr. Hansjörg Schild