Project Details
Projekt
EXC 115: Macromolecular Complexes
Subject Area
Basic Research in Biology and Medicine
Term
from 2006 to 2019
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 24286296
Macromolecular complexes participate in all fundamental aspects of life. Owing to their sheer size, scarcity or fragility, most of these complexes are largely unexplored in terms of their structure and molecular mechanisms, yet their crucial role in virtually all cellular processes is apparent. Frankfurt is a renowned centre in structural biology with a special emphasis on proteins and protein complexes in biological membranes, where collaborative efforts between research groups at the University and the Max Planck Institutes have already produced exceptional results. The Cluster of Excellence Frankfurt (CEF) aims to extend this outstanding potential to other large macromolecular assemblies.
A group of internationally leading scientists has joined forces to address the structure, function, mechanisms and dynamic assembly of macromolecular complexes using an unparalleled range of powerful techniques, which will be developed further in this cluster of excellence. Our goal is not only to understand how proteins are organised in macromolecular complexes and how this affects their function but also to comprehend their roles in the inner workings of cells and to use this knowledge in the design of new drugs.
A group of internationally leading scientists has joined forces to address the structure, function, mechanisms and dynamic assembly of macromolecular complexes using an unparalleled range of powerful techniques, which will be developed further in this cluster of excellence. Our goal is not only to understand how proteins are organised in macromolecular complexes and how this affects their function but also to comprehend their roles in the inner workings of cells and to use this knowledge in the design of new drugs.
DFG Programme
Clusters of Excellence
Applicant Institution
Goethe-Universität Frankfurt am Main
Participating Institution
Max-Planck-Institut für Biophysik; Max-Planck-Institut für Hirnforschung
Spokespersons
Professor Dr. Volker Dötsch; Professor Dr. Harald Schwalbe, until 3/2013
Participating Researchers
Professorin Dr. Amparo Acker-Palmer; Professor Dr. Ulrich Brandt; Professorin Dr. Stefanie Dimmeler; Professor Dr. Achilleas Frangakis; Professorin Dr. Simone Fulda; Professor Dr. Clemens Glaubitz; Professor Dr. Alexander Gottschalk; Professor Dr. Alexander Heckel; Professor Dr. Michael Karas; Professorin Dr. Ina Koch; Professor Dr. Rolf Marschalek; Professor Dr. Thomas Meier; Professor Dr. Hartmut Michel; Professor Dr. Heinz Dieter Osiewacz; Professor Dr. Thomas F. Prisner; Professor Dr. Enrico Schleiff; Professorin Dr. Erin M. Schuman; Professor Dr. Ernst H.K. Stelzer; Professor Dr. Robert Tampé; Professor Dr. Josef Wachtveitl
