FOR 2177:  Integrated Chemical Micro Laboratories

Chemistry in miniaturized systems in which (bio)-chemical processestake place in microchannels or cavities is a very active field ofresearch. In recent years, impressive scientific progress has beenachieved in micro reaction technology as well as in the miniaturizationof analytical methods and technologies. Despite intense researchefforts are made in these single disciplines all around the world, theirefficient combination is still largely in its infancy. The intention of theresearch unit “Integrated Chemical Micro Laboratories (In-CheM)” isto meet this particular challenge and to synergistically bridge the gapbetween highly topical approaches in (bio)-organic synthesis andchemical analysis in micro systems. To achieve this interdisciplinarygoal, a team of scientists performs fundamental research in the fieldsof (bio-) chemical transformations in chips or micro reactors. A strongfocus is the combination of chemical synthesis with analyticaltechniques to inline characterize the processes in real-time. By closecooperation of experienced scientists from analytics and synthesisoriented disciplines of (bio-) chemistry, significant progress in the areaof integrated synthesis and analysis labs is expected. Prominentapplication fields of such innovation can contribute in the field of, forexample, drug discovery, assembly of substance libraries, control ofcatalytic reactions and the elucidation of reaction mechanism.Attributed to the strong regional cluster of experts in the fields of labon-a-chip technology, analytical chemistry and synthetic (bio-) organicchemistry, the research area Leipzig-Berlin represents an almost idealbasis for a regionally focused research unit dedicated to meet thesescientific challenges.

DFG Programme Research Units

International Connection Italy

• Advanced technologies for integrated micro systems (Applicants Belder, Detlev ;  Jahnke, Heinz-Georg )
• Continuous flow synthesis of sulfur heterocycles via cycloaddition reactions of photochemically generated transient thioaldehydes (Applicant Schneider, Christoph )
• Coordination Funds (Applicant Belder, Detlev )
• Empirical understanding of glycosylation reactions (Applicant Seeberger, Peter H. )
• FluxProbe - Using biocatalysis for probing the functional space of single microbial catalysts (Applicant Schmid, Andreas )
• From discrete particle to single cell catalysis (Applicant Belder, Detlev )
• Impedimetric monitoring in microfluidic reaction systems for small molecule detection in flow (Applicant Robitzki, Andrea A. )
• Inline characterization in microfluidic reaction systems by SERS (Applicant Kneipp, Janina )
• Mechanisms of organic reactions in complex environments and confined volumes elucidated by laser desorption mass and ion mobility spectrometry (Applicants Abel, Bernd ;  Löhmannsröben, Hans-Gerd )
• Microfluidic trapping of 3D spheres in microfluidic reaction systems for real time biosensing of flow chemistry derived compounds (Applicant Jahnke, Heinz-Georg )
• Multicatalytic synthesis with 1,3-dipoles in microfluidic systems (Applicant Zeitler, Kirsten )
• Multistep chip reactors with an integrated continuous separation (Applicant Belder, Detlev )
• Novel chemical tools to elucidate carbohydrate chemistry (Applicants Pagel, Kevin ;  Seeberger, Peter H. )
• Synergistic Photocatalysis with short-lived intermediates in microfluidic systems (Applicant Zeitler, Kirsten )

Spokesperson Professor Dr. Detlev Belder