Die Bedeutung des Inflammasoms bei Hyperoxalurischen Nierenerkrankungen
Zusammenfassung der Projektergebnisse
Our work in this DFG project has brought new insights into the role of oxalate in chronic kidney disease. Specifically, we have developed a murine model of oxalate-induced chronic kidney disease. Using this model we have defined the inflammatory and signaling pathways responsible for mediating oxalate-induced inflammation and subsequent organ fibrosis. Our murine model has been shown useful to other groups of investigators, allowing to examine the mechanisms of crystal adhesion and progression of CKD in general. Moreover, as part of our work we have established a protocol to measure plasma oxalate concentrations, validated our assay accuracy in samples of patients with end stage kidney disease. This has led to new translational projects beyond the original aims of this project. The major findings obtained as part of this research proposal have now been integrated in a larger research collaboration as part of the newly funded SFB 1365: Nephroprotektion.
Projektbezogene Publikationen (Auswahl)
- “An update on the role of the inflammasomes in the pathogenesis kidney diseases.” Pediatr Nephrol. (2015)
Darisipudi M, Knauf F
(Siehe online unter https://doi.org/10.1007/s00467-015-3153-z) - Core curriculum in Nephrology – Update on Nephrolithiasis. American Journal of Kidney Diseases (2016)
Pfau A, Knauf F
(Siehe online unter https://doi.org/10.1053/j.ajkd.2016.05.016) - Oxalate, inflammasome, and progression of kidney disease. Current Opinion in Nephrology and Hypertension (2016)
Ermer T, Eckardt KU, Aronson PS, Knauf F
(Siehe online unter https://doi.org/10.1097/MNH.0000000000000229) - “Oxalate-induced chronic kidney disease with its uremic and cardiovascular complications.” Am J Physiol Renal Physiol. (2016)
Mulay S, Eberhard J, Pfann V, Marschner J, Darisipudi M, Daniel C, Romoli S, Desai J, Grigorescu M, Kumar S, Rathkolb, Eckhard Wolf, Martin Hrabě de Angelis, Tobias Bäuerle, Barbara Dietel, Kerstin Amann, Carsten A. Wagner, Kai-Uwe Eckardt, Peter S. Aronson, Hans Joachim Anders, Knauf F
(Siehe online unter https://doi.org/10.1152/ajprenal.00488.2015) - Impact of Regular or Extended Hemodialysis and Hemodialfiltration on Plasma Oxalate Concentrations in Patients With End-Stage Renal Disease. Kidney Int Rep. (2017)
Ermer T, Kopp C, Asplin JR, Granja I, Perazella MA, Reichel M, Nolin TD, Eckardt KU, Aronson PS, Finkelstein FO, Knauf F
(Siehe online unter https://doi.org/10.1016/j.ekir.2017.06.002) - Characterization of renal NaCl and oxalate transport in Slc26a6-/- mice. Am J Physiol Renal Physiol. (2019)
Knauf F, Velazquez H, Pfann V, Jiang Z, Aronson PS
(Siehe online unter https://doi.org/10.1152/ajprenal.00309.2018)
