Project Details
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The Role of the Inflammasome in Hyperoxaluric Kidney Disease

Subject Area Nephrology
Term from 2014 to 2018
Project identifier Deutsche Forschungsgemeinschaft (DFG) - Project number 258451658
 
Final Report Year 2019

Final Report Abstract

Our work in this DFG project has brought new insights into the role of oxalate in chronic kidney disease. Specifically, we have developed a murine model of oxalate-induced chronic kidney disease. Using this model we have defined the inflammatory and signaling pathways responsible for mediating oxalate-induced inflammation and subsequent organ fibrosis. Our murine model has been shown useful to other groups of investigators, allowing to examine the mechanisms of crystal adhesion and progression of CKD in general. Moreover, as part of our work we have established a protocol to measure plasma oxalate concentrations, validated our assay accuracy in samples of patients with end stage kidney disease. This has led to new translational projects beyond the original aims of this project. The major findings obtained as part of this research proposal have now been integrated in a larger research collaboration as part of the newly funded SFB 1365: Nephroprotektion.

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