Die Rolle des microsomalen Triglycerid-Transferproteins in Maus-Modellen chronisch entzündlicher Darmerkrankungen

• Applicant: Professor Dr. Sebastian Zeissig
• Subject Area: Gastroenterology
• Term: from 2006 to 2009
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 28115764

• Final Report Year: 2009

Final Report Abstract

In conclusion, we have shown that hepatocytes directly regulate CD1d-restricted antigen presentation via MTP. These data reveal a previously unrecognized mechanism by which hepatocytes can directly modulate immune cell composition and activation in the liver which has important implications for a wide variety of metabolic and immune-mediated liver diseases that derive from alterations in the normally tolerogenic environment of the liver.

Publications

• Role of NKT cells in the digestive system. III. Role of NKT cells in intestinal immunity, Am J Physiol Gastrointest Liver Physiol, 2007. 293(6): p. G1101-5
  Zeissig, S., Kaser, A., Dougan, S.K., Nieuwenhuis, E.E., Blumberg, R.S.
  
• Das Microsomale Triglyzerid-Transferprotein (MTP) beeinflusst die CD1d-vermittelte Antigen-Präsentation von Hepatozyten und reguliert die periphere Natural Killer T (NKT)-Zell Homöostase. (DGVS, Jahrestagung 2008)
  Zeissig, S., Kaser, A., Dougan, S.K., Blumberg, R.S.
  
• Microsomal triglyceride transfer protein regulates CD1d-restricted antigen presentation of hepatocytes and controls natural killer T cell homeostasis via CD1d-mediated apoptosis. (Digestive Disease Week, 2008)
  Zeissig, S., Kaser, A., Dougan, S.K., Blumberg, R.S.
  
• Microsomal triglyceride transfer protein regulates endogenous and exogenous antigen presentation by group 1 CD1 molecules. Eur J Immunol, 2008. 38(8): p. 2351-9
  Kaser, A., Hava, D.L., Dougan, S.K., Chen, Z., Zeissig, S., Brenner, M.B., Blumberg, R.S. et al.
  
• XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease. Cell, 2008. 134(5): p. 743-56
  Kaser, A., Lee, A.H., Franke, A., Glickman, J.N., Zeissig, S., Tilg, H., Nieuwenhuis, E.E., Higgins, D.E., Schreiber, S., Glimcher, L.H., Blumberg, R.S.