Project Details
Projekt
Innate and innate-like lymphocytes in immune-mediated glomerular diseases (A06)
Subject Area
Nephrology
Term
since 2016
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 264599542
By using sc(nuc)RNAseq and spatial tissue analyses (spatial transcriptomics and imaging) we will decipher transcriptional programs and spatial distribution of innate-like T cells and neighboring kidney epithelial cells in different entities of immune-mediated glomerular diseases (ANCA glomerulonephritis, Lupus nephritis, IgA nephropathy). Next, novel complex immune cell – 3D kidney organoid systems will be employed to model kidney diseases in vitro with human cells and investigate the regulation of kidney epithelial cells by innate-like T cells. Finally, selected candidate pathways will be functionally validated in mouse models of glomerulonephritis. In summary, our studies will elucidate the role of innate-like T cells in immune-mediated glomerular diseases and identify targets to develop tailored treatment approaches in patients with glomerulonephritis.
DFG Programme
Collaborative Research Centres
Subproject of
SFB 1192:
Immune-Mediated Glomerular Diseases - Basic Concepts and Clinical Implications -
Applicant Institution
Universität Hamburg
