Project Details
Projekt
Myeloid immune cell subsets and the renal microenvironment in glomerulonephritis (A08)
Subject Area
Nephrology
Term
since 2016
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 264599542
This project addresses the roles and cross-talk of myeloid immune cells, including mononuclear phagocytes (MNP, expertise Kurts) and neutrophilic granulocytes (PMN, expertise new co-applicant von Vietinghoff), in crescentic glomerulonephritis (cGN). Our bioinformatic analysis of the first true spatiotemporal single cell sequencing (scRNASeq) dataset in a mouse cGN model that we generated during the previous CRC funding period uncovered potential new myeloid pathomechanisms that we wish to explore. By investigating myeloid cell, specifically PMN and MNP subtype interaction and their relation to the renal osmolyte gradient, our project aims at delineating organ- and stage-specific approaches to management of myeloid cell-driven inflammation in glomerulonephritis.
DFG Programme
Collaborative Research Centres
Subproject of
SFB 1192:
Immune-Mediated Glomerular Diseases - Basic Concepts and Clinical Implications -
Applicant Institution
Universität Hamburg
