Evolution of the regulatory landscape in hematopoietic malignancies (A03)

• Subject Area: Hematology, Oncology ; Human Genetics
• Term: from 2016 to 2019
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 278529602

Epigenetic mechanisms are central for transcriptional regulation and mediate adaptation to changing environmental settings. How epigenetic changes influence cancer evolution is currently unclear. We want to determine the regulatory landscape of human AML by investigating enhancer chromatin modifications (H3K27ac) in AML diagnosis and relapse samples. These studies will uncover the important regulatory regions that are critical for AML development and progression, and may therefore, in the future, lead to novel therapeutic strategies for AML treatment.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1243: Genetic and Epigenetic Evolution of Hematopoietic Neoplasms
• Applicant Institution: Ludwig-Maximilians-Universität München
• Project Head: Professor Dr. Gunnar Schotta