Project Details
Projekt
Assessing genetic and epigenetic heterogeneity in hematopoietic neoplasms using single cell genomics (A14)
Subject Area
General Genetics and Functional Genome Biology
Bioinformatics and Theoretical Biology
Evolution, Anthropology
Bioinformatics and Theoretical Biology
Evolution, Anthropology
Term
from 2016 to 2020
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 278529602
Understanding treatment resistance of AML requires to know how fast genetic, epigenetic and transcriptional heterogeneity can evolve. Here, we will use and develop genomic technologies allowing to measure expression, subclonal genotypes and cellular barcodes from single AML cells obtained from series of treated and untreated patient-derived xenograft (PDX) mice. Combined with single-molecule measurements of genetic and epigenetic heterogeneity, this will allow to disentangle molecular levels of clonal evolution and to better model and treat the emergence of resistant AML clones.
DFG Programme
Collaborative Research Centres
Applicant Institution
Ludwig-Maximilians-Universität München
Project Head
Professor Dr. Wolfgang Enard
