Functional genome analysis of genetic and epigenetic evolution of hematopoetic neoplasms by next generation sequencing (Z02)

• Subject Area: Biology
• Term: from 2016 to 2020
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 278529602

High throughput sequencing of short DNA fragments is a powerful tool to study hematopoietic neoplasms. Sequencing with Nanopores also interrogates long native DNA and RNA and thus captures structural variations and modified nucleotides. We will provide our knowledge to perform and evaluate both short and long read high throughput sequencing. Furthermore, we will operate and expand the central IT platform of this CRC for the documentation, comparative analysis of results and visualization of various findings.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1243: Genetic and Epigenetic Evolution of Hematopoietic Neoplasms
• Applicant Institution: Ludwig-Maximilians-Universität München
• Project Head: Dr. Helmut Blum