Project Details
Kinase signaling driving “pseudo-malignant” lung vascular remodeling – therapeutic exploitation (A08)
Subject Area
Pneumology, Thoracic Surgery
Term
since 2016
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 268555672
Structural pulmonary vascular remodeling is a hallmark of pulmonary hypertension (PH), which is characterized by excessive proliferation, apoptosis resistance, and migration of pulmonary vascular cells. We aim to identify kinases that are responsible for this phenotype and to study the functional consequences of their inhibition in cell culture experiments. In addition, kinome studies using peripheral blood derived mononuclear cells as well as plasma proteomic analysis should reveal pathological alterations and might serve as predictors of drug responsiveness. Finally, the therapeutic efficacy of novel kinase inhibitors will be addressed in clinically relevant animal models of PH.
DFG Programme
Collaborative Research Centres
Subproject of
SFB 1213:
Pulmonary Hypertension and Cor Pulmonale
Applicant Institution
Justus-Liebig-Universität Gießen
Project Heads
Professor Dr. Friedrich Grimminger; Professor Dr. Ralph Schermuly