Project Details
Epigenetic control of pulmonary vessels and the right heart in development and disease: the role of Suv4-20h1 (B02)
Subject Area
Cardiology, Angiology
Term
since 2016
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 268555672
Development of the cardiovascular and pulmonary systems is tightly interconnected. We found that the histone methyltransferase Suv4-20h1 is required in cardio-pulmonary progenitor cells (CPP) to control subsequent proliferation of smooth muscle cells (SMC), maturation of the microvasculature and lung alveolarization, putatively via regulation of SOD3 expression. We will investigate the communication between endothelial cells and SMC and determine which particular CPP-derivative is responsible for the Suv4-20h1 phenotype. Furthermore, we will analyze the potential crosstalk of H4K20me2/3 with other histone modifications, and investigate the chromatin landscape linked to heart and lung defects in Suv4-20h1 (R143C) animals.
DFG Programme
Collaborative Research Centres
Subproject of
SFB 1213:
Pulmonary Hypertension and Cor Pulmonale
Applicant Institution
Justus-Liebig-Universität Gießen
Project Heads
Professor Dr. Thomas Braun; Dr. Xuejun Yuan; Dr. Yonggang Zhou, Ph.D., until 4/2016 (†)