Project Details
Projekt
Changes in chromatin organization and protein networks in right heart failure (B03)
Subject Area
Cell Biology
Term
since 2016
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 268555672
Pulmonary artery banding in weanling rats will be used to study the transition from compensated (adaptive) right ventricular (RV) hypertrophy to RV failure. By performing pulmonary or aortic artery banding models in weanling rats we found profound functional and transcriptional stage- and ventricle-specific differences in the adaptation of the heart to chronic pressure overload. Bioinformatic analyses implicate deregulated phosphatase networks in this process. By comparative deep molecular phenotyping we will unravel the changes in signal transduction and in chromatin and proteome landscapes upon RV or LV failure and the contribution of deregulated protein networks to right heart pathology. Based on these data we will also explore novel therapeutic targets in cardiac signaling.
DFG Programme
Collaborative Research Centres
Subproject of
SFB 1213:
Pulmonary Hypertension and Cor Pulmonale
Applicant Institution
Justus-Liebig-Universität Gießen
