SoSexOT - Entschlüsselung des Oxytocin-Netzwerkes, welches sozial-sexuelles Verhalten steuert

• Antragsteller: Professor Dr. Valery Grinevich
• Fachliche Zuordnung: Kognitive, systemische und Verhaltensneurobiologie
• Förderung: Förderung von 2016 bis 2020
• Projektkennung: Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 316694078

• Erstellungsjahr: 2020

Zusammenfassung der Projektergebnisse

Our ongoing anatomical study implementing retrograde rabies-based tracing, which revealed that parvocellular OT neurons receive at least 10-fold more inputs (preferentially from thalamic and brainstem regions) than magnocellular OT neurons. This together with functional data allows us to hypothesize that parvocellular oxytocin cells preferentially receive an input - via brainstem and thalamus - from sensory neurons of the spinal cord, and that they can, in turn, activate magnocellular oxytocin cells which modulate social behaviors by their projections to socially-relevant brain regions.

Projektbezogene Publikationen (Auswahl)

• (2019): A fear memory engram and its plasticity in the hypothalamic oxytocin system. Neuron, 103, 133-146
  Hasan, M.T., Althammer, F., da Silva Gouveia, M., Goyon, S., Eliava, M., Lefevre, A., Kerspern, D., Schimmer, J., Raftogianni, A., Wahis, J., Knobloch-Bollmann, H.S., Tang, Y., Liu, X., Jain, A., Chavant, V., Goumon, Y., Weislogel, J.-M., Hurlemann, R., Herpertz, S.C., Pitzer, C., Darbon, P., Dogbevia, G.K., Bertocchi, I., Larkum, M.E., Sprengel, R., Bading, H., Charlet, A. and Grinevich, V.
  (Siehe online unter https://doi.org/10.1016/j.neuron.2019.04.029)
• (2019): Chemogenetic activation of oxytocin neurons: Temporal dynamics, hormonal release, and behavioral consequences. Psychoneuroendocrinology 106, 77-84
  Grund, T., Tang, Y., Benusiglio, D., Althammer, F., Probst, S., Oppenlander, L., Neumann, I.D., and Grinevich, V.
  (Siehe online unter https://doi.org/10.1016/j.psyneuen.2019.03.019)
• Social touch promotes inter-female communication via activation of parvocellular oxytocin neurons. Nature Neurosci. (2020)
  Tang, Y., Benusiglio, D., Lefevre, A., Hilfiger, L., Althammer, F., Bludau, A., Hagiwara, D., Baudon, A., Darbon, P., Schimmer, J., Kirchner, M.K., Roy, R.K., Wang, S., Eliava, M., Wagner, S., Oberhuber, M., Conzelmann, K.K., Schwarz, M., Stern, J.E., Leng, G., Neumann, I.D., Charlet, A., Grinevich, V.
  (Siehe online unter https://doi.org/10.1038/s41593-020-0674-y)