Developing a zebrafish model to identify novel mediators of resilience mechanisms (A04)

• Subject Area: Molecular Biology and Physiology of Neurons and Glial Cells
• Term: from 2016 to 2020
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 264810226

A04 will exploit the short generation times, space-saving housing and excellent genetic manipulability afforded by zebrafish. They develop the first zebrafish model of resilience to chronic stress, which will serve to discover new molecular candidates. Further, A04 applies BONCAT and FUNCAT techniques that allow for identifying newly synthesized (stressor-induced) synaptic proteins in a regionally specific manner. Also, they will use the model to validate discovered candidates by a battery of loss-offunction and gain-of-function approaches that are already well established in zebrafish.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1193: Neurobiology of Resilience to stress-related mental dysfunction: from understanding mechanisms to promoting prevention
• Applicant Institution: Johannes Gutenberg-Universität Mainz
• Co-Applicant Institution: Max-Planck-Institut für Hirnforschung
• Project Heads: Professorin Soojin Ryu, Ph.D.; Professorin Dr. Erin M. Schuman