Deciphering the epigenetic basis of resilience (A05)

• Subject Area: Biological Psychiatry
• Term: from 2016 to 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 264810226

Having analyzed epigenetic modifications in resilient mice by applying different NGS technologies in the first funding period, the second funding period will be dedicated to study epigenetic mechanisms of resilience formation and to apply epigenetic drug treatment. To do so epigenetic candidate factors identified from omics studies of the first funding period will be examined for their role in resilience formation. The classical as well as the modified test setting (Modified Social Interaction Test) will be used. Epigenetic drug treatment will be continued and expanded in the second funding period. Promising results could already be obtained with the HDACi Ci-994.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1193: Neurobiology of Resilience to stress-related mental dysfunction: from understanding mechanisms to promoting prevention
• Applicant Institution: Johannes Gutenberg-Universität Mainz
• Project Heads: Professorin Dr. Susann Schweiger; Privatdozentin Dr. Jennifer Winter, Ph.D., since 12/2019