Impact of proteostasis and the ubiquitin proteasome system on myeloid cell function in the CNS (A04)

• Subject Area: Molecular and Cellular Neurology and Neuropathology
• Term: from 2017 to 2020
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 259373024

During innate immune responses, proteostasis is severely challenged by inflammatory damage. Therefore, a well-adapted clearance capacity for damaged proteins by the ubiquitin proteasom system (UPS) is pivotal for myeloid cells to cope with such situations. Proteasome dysfunction can cause autoinflammation with a significant interferon signature. This project aims to investigate the role of the UPS for gene expression programs and microglia cell function under physiological and pathological conditions in vitro, ex vivo and in vivo. Another major objective is the elucidation of the signaling pathway leading from damaged protein to an IFN-response in molecular detail.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 167: Development, function and potential of myeloid cells in the central nervous system (NeuroMac)
• Applicant Institution: Albert-Ludwigs-Universität Freiburg
• Project Head: Professorin Dr. Elke Beate Krüger