Project Details
Projekt
Myeloid cells in the development of choroidal neovascularisation in the eye (B02)
Subject Area
Molecular and Cellular Neurology and Neuropathology
Term
from 2017 to 2020
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 259373024
Myeloid cells, including resident microglia (MG) and infiltrating macrophages (Mac) have been implicated in the development of choroidal neovascularisation (CNV) in age-related macular degeneration (AMD). Using two novel transgenic reporter mouse models for lineage tracing and fate mapping studies we will clarify the origin, dynamics and differential function of MG and Macs during ageing and CNV development. These studies will improve our understanding of the immunological processes in neovascular AMD and may lay the foundation for the development of novel improved therapeutic approaches.
DFG Programme
CRC/Transregios
Subproject of
TRR 167:
Development, function and potential of myeloid cells in the central nervous system (NeuroMac)
Applicant Institution
Albert-Ludwigs-Universität Freiburg
