Dynamic compartmentalization of myeloid cell responses in neuroinflammation (B05)

• Subject Area: Molecular and Cellular Neurology and Neuropathology
• Term: since 2017
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 259373024

Neuroinflammation is a common feature of autoimmune CNS diseases such as multiple sclerosis(MS). Our previous study suggests that myeloid cell responses in early MS may be related to the morecompartmentalized inflammation in the CNS. In this study we shall characterize the distinctphenotypes of myeloid cells in the peripheral blood, cerebrospinal fluid, choroid plexus and the brainof MS donors using mass cytometry and imaging mass cytometry. Furthermore, the dynamic cellsignalling of myeloid cells from different compartments will be assessed using co- and/or multipleprimarycell culture approaches.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 167: Development, function and potential of myeloid cells in the central nervous system (NeuroMac)
• Applicant Institution: Albert-Ludwigs-Universität Freiburg
• Project Heads: Privatdozentin Dr. Chotima Böttcher; Professor Dr. Josef Priller, until 12/2020