Circadian regulation of myeloid cell function in neurodegenerative diseases (B07)

• Subject Area: Molecular and Cellular Neurology and Neuropathology
• Term: since 2017
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 259373024

We hypothesize that circadian and immune abnormalities are closely interconnected in Alzheimer’sdisease (AD) and Huntington’s disease (HD). In this project, we shall characterize diurnal/circadian rhythms and their entrainment in microglia and border-associated macrophages of the brain, and myeloid cells from liver, skin and blood of wild type mice and transgenic mouse models of HD and AD.We shall conditionally delete the circadian clock gene Bmal1 in microglia to test the consequences for neural function. Finally, we shall generate human microglia-like cells from induced pluripotent stem cells to test the impact of clock disruption in myeloid cells for neurodegenerative diseases.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 167: Development, function and potential of myeloid cells in the central nervous system (NeuroMac)
• Applicant Institution: Albert-Ludwigs-Universität Freiburg
• Project Head: Professor Dr. Josef Priller