Dissecting the crosstalk between myeloid cells, pericytes and lymphocytes for autoimmunemediated mechanisms underlying post-stroke cognitive decline (B12)

• Subject Area: Molecular and Cellular Neurology and Neuropathology
• Term: since 2017
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 259373024

In the chronic phase of stroke, we found that B cells cluster with T cells and myeloid cells withinectopic lymphoid structures (ELS) in the ischemic brain. Post-stroke cognitive decline was previouslyassociated with brain-infiltrating B cells and autoantibodies in patients and animal models. Wehypothesize that brain myeloid cells together with lymphocytes are essential for the induction ofpericyte-derived lymphoid tissue organizer-like cells, which provide essential cues for B cellrecruitment and differentiation within ELS. Understanding this crosstalk during ELS formation mightlead to causal treatments of post-stroke dementia.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 167: Development, function and potential of myeloid cells in the central nervous system (NeuroMac)
• Applicant Institution: Albert-Ludwigs-Universität Freiburg
• Project Heads: Professor Dr. Andreas Meisel; Dr. Christian Alexander Meisel