Role of microglia in chronic inflammation and long-term consequences after stroke (B12)

• Subject Area: Molecular and Cellular Neurology and Neuropathology ; Clinical Neurology; Neurosurgery and Neuroradiology
• Term: since 2017
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 259373024

Inflammation and immune responses play a crucial role in the development and progression of stroke. We aim to investigate the impact of stroke-induced chronic inflammation on microglial cell function and its contribution to post-stroke cognitive decline in the aging brain. We will perform molecular and cellular analysis of microglia in young and aged mice with and without stroke-associated pulmonary infections. We will identify specific molecular mechanisms that modulate microglial neuroprotective phenotype during the chronic phase of stroke. Human CSF and post-mortem brain specimens will also be analyzed to consolidate the findings.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 167: Development, function and potential of myeloid cells in the central nervous system (NeuroMac)
• Applicant Institution: Technische Universität München (TUM)
• Project Heads: Professor Dr. Andreas Meisel; Dr. Christian Alexander Meisel, until 12/2024; Dr. Shima Safaiyan, since 1/2025