Project Details
Projekt
EXC 171: Microscopy at the Nanometer Range (within DFG Research Centre CMPB)
Subject Area
Neurosciences
Basic Research in Biology and Medicine
Medicine
Basic Research in Biology and Medicine
Medicine
Term
from 2006 to 2018
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 32501626
A central programme of the DFG Research Centre "Molecular Physiology of the Brain (CMPB)" in general, beyond aiming for a basic understanding, is human neurological and psychiatric disease.
This theme is focussed in particular on the alterations associated with developmental changes originating either from the deleterious effects of genetic mutation or deletion, or changes causing neurodegenerative diseases. We anticipate that this research programme will ultimately lead to new diagnostic tools and rational therapeutic strategies both for the protection against and the treatment of neurological and psychiatric disorders such as Parkinson's disease or Schizophrenia.
The CMPB is using the additional funding secured by the recognition as cluster of excellence to create a concerted effort in microscopy at the nanometer range. All microscopy and spectroscopy techniques are inherently limited with respect to spatial and temporal resolution, as well as sample volume, control of microenvironment, and chemical sensitivity. The aim here will be to develop a complementary set of techniques which jointly will overcome such limitations, and thereby to gain a three-dimensional, high-resolution spatio-temporal visualisation of the molecular interactions underlying the biochemical machinery of living cells. In order to achieve this aim the cluster of excellence integrates expertise from research disciplines as various as physics, genetics, anatomy, biochemistry, cell and molecular biology, physiology and clinical research. The research groups are embedded in the existing neuroscience and biophysics units of the CMPB and will be able to immediately profit from the advanced technical capabilities of the existing groups. Being positioned between technology development and biological and medical applications the research groups will guarantee a close connection between these areas, and are expected to form the nucleus for long-lasting structures at this important interface.
This theme is focussed in particular on the alterations associated with developmental changes originating either from the deleterious effects of genetic mutation or deletion, or changes causing neurodegenerative diseases. We anticipate that this research programme will ultimately lead to new diagnostic tools and rational therapeutic strategies both for the protection against and the treatment of neurological and psychiatric disorders such as Parkinson's disease or Schizophrenia.
The CMPB is using the additional funding secured by the recognition as cluster of excellence to create a concerted effort in microscopy at the nanometer range. All microscopy and spectroscopy techniques are inherently limited with respect to spatial and temporal resolution, as well as sample volume, control of microenvironment, and chemical sensitivity. The aim here will be to develop a complementary set of techniques which jointly will overcome such limitations, and thereby to gain a three-dimensional, high-resolution spatio-temporal visualisation of the molecular interactions underlying the biochemical machinery of living cells. In order to achieve this aim the cluster of excellence integrates expertise from research disciplines as various as physics, genetics, anatomy, biochemistry, cell and molecular biology, physiology and clinical research. The research groups are embedded in the existing neuroscience and biophysics units of the CMPB and will be able to immediately profit from the advanced technical capabilities of the existing groups. Being positioned between technology development and biological and medical applications the research groups will guarantee a close connection between these areas, and are expected to form the nucleus for long-lasting structures at this important interface.
DFG Programme
Clusters of Excellence
Applicant Institution
Georg-August-Universität Göttingen
Participating Institution
Deutsches Primatenzentrum GmbH (DPZ)
Leibniz-Institut für Primatenforschung; Institut für Nanophotonik Göttingen e.V. (IFNANO); Klinikum Kassel GmbH; Max-Planck-Institut für biophysikalische Chemie
(Karl-Friedrich-Bonhoeffer-Institut) (aufgelöst); Max-Planck-Institut für experimentelle Medizin (aufgelöst); XLAB - Göttinger Experimentallabor für junge Leute e.V.
Leibniz-Institut für Primatenforschung; Institut für Nanophotonik Göttingen e.V. (IFNANO); Klinikum Kassel GmbH; Max-Planck-Institut für biophysikalische Chemie
(Karl-Friedrich-Bonhoeffer-Institut) (aufgelöst); Max-Planck-Institut für experimentelle Medizin (aufgelöst); XLAB - Göttinger Experimentallabor für junge Leute e.V.
Spokespersons
Professor Dr. Silvio-Olivier Rizzoli, Ph.D.; Professor Dr. Detlev Schild, until 9/2016
Participating Researchers
Professor Dr. Nils Brose; Professor Dr. Ulf Diederichsen (†); Professorin Dr. Hannelore Maria Ehrenreich; Professor Dr. Jörg Enderlein; Professor Dr. André Fischer; Professor Dr. Christian Griesinger; Professorin Dr. Claudia Höbartner; Professor Dr. Reinhard Jahn; Professor Dr. Stefan Jakobs; Professorin Dr. Sarah Köster; Professor Dr. Tobias Moser; Professor Dr. Erwin Neher; Professor Dr. Tiago Fleming Outeiro; Professor Dr. Diethelm Wolfgang Richter; Professorin Dr. Marina V. Rodnina; Professor Dr. Tim Salditt; Professor Dr. Christoph Friedrich Schmidt; Professorin Dr. Anastassia Stoykova; Professorin Dr. Melanie Wilke; Professor Dr. Andreas Wodarz; Professor Dr. Fred S. Wouters
