Integrative nukleäre Modulation des Hedgehog Transkriptionsprofils (.2)

• Antragsteller: Professor Dr. Matthias Lauth
• Fachliche Zuordnung: Zellbiologie ; Biochemie
• Förderung: Förderung von 2016 bis 2020
• Projektkennung: Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 329203264

• Erstellungsjahr: 2021

Zusammenfassung der Projektergebnisse

In summary, we can conclude that project was completed successfully. While the initial hypothesis later turned out to be invalid (at least in our biological system), we could shift the project towards a very successful direction. Specifically, we could make significant progress in the understanding of how mechanics and substrate stiffness affects Hh signaling and metabolic regulation. To this end, publishable data sets were generated which can be used by us and others to move the field forward.

Projektbezogene Publikationen (Auswahl)

• (2019): DYRK1B regulates Hedgehog-induced microtubule acetylation. Cell Mol Life Sci 76 (1), S. 193–207
  Singh, R.; Holz, P. S.; Roth, K.; Hupfer, A.; Meissner, W.; Muller, R. et al.
  (Siehe online unter https://doi.org/10.1007/s00018-018-2942-5)
• (2021): Activation of Cilia-Independent Hedgehog/GLI1 Signaling as a Novel Concept for Neuroblastoma Therapy. Cancers 13 (8), S. 1908
  Koeniger, Anke; Brichkina, Anna; Nee, Iris; Dempwolff, Lukas; Hupfer, Anna; Galperin, Ilya et al.
  (Siehe online unter https://doi.org/10.3390/cancers13081908)
• (2021): The mammalian Hedgehog pathway is modulated by ANP32 proteins. Biochemical and biophysical research communications 553, S. 78–84
  Hupfer, Anna; Brichkina, Anna; Adhikary, Till; Lauth, Matthias
  (Siehe online unter https://doi.org/10.1016/j.bbrc.2021.03.027)