Integrative nuclear modulation of the Hedgehog transcriptional profile (.2)

• Applicant: Professor Dr. Matthias Lauth
• Subject Area: Cell Biology ; Biochemistry
• Term: from 2016 to 2020
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 329203264

• Final Report Year: 2021

Final Report Abstract

In summary, we can conclude that project was completed successfully. While the initial hypothesis later turned out to be invalid (at least in our biological system), we could shift the project towards a very successful direction. Specifically, we could make significant progress in the understanding of how mechanics and substrate stiffness affects Hh signaling and metabolic regulation. To this end, publishable data sets were generated which can be used by us and others to move the field forward.

Publications

• (2019): DYRK1B regulates Hedgehog-induced microtubule acetylation. Cell Mol Life Sci 76 (1), S. 193–207
  Singh, R.; Holz, P. S.; Roth, K.; Hupfer, A.; Meissner, W.; Muller, R. et al.
  (See online at https://doi.org/10.1007/s00018-018-2942-5)
• (2021): Activation of Cilia-Independent Hedgehog/GLI1 Signaling as a Novel Concept for Neuroblastoma Therapy. Cancers 13 (8), S. 1908
  Koeniger, Anke; Brichkina, Anna; Nee, Iris; Dempwolff, Lukas; Hupfer, Anna; Galperin, Ilya et al.
  (See online at https://doi.org/10.3390/cancers13081908)
• (2021): The mammalian Hedgehog pathway is modulated by ANP32 proteins. Biochemical and biophysical research communications 553, S. 78–84
  Hupfer, Anna; Brichkina, Anna; Adhikary, Till; Lauth, Matthias
  (See online at https://doi.org/10.1016/j.bbrc.2021.03.027)