Novel diagnostic, therapeutic and monitoring options in congenital adrenal hyperplasia (A04)

• Subject Area: Endocrinology, Diabetology, Metabolism ; Pediatric and Adolescent Medicine
• Term: since 2017
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 314061271

Central aim of project A04 is to use the established mouse models for congenital adrenal hyperplasia (CAH) as well as the clinical data and biosamples collected in the CAH registry to gain a better understanding of the pathophysiological processes and to develop new therapeutic options for CAH. We will use our mouse models to establish a cell therapy with human induced steroid-producing cells derived from human embryonic stem cells. We will study fertility disorders and dysregulated immune phenotype in CAH mice. With the CAH-registry, we will perform important translational studies also focusing on fertility, immune phenotype and biomarkers in CAH. The final goal is to enable personalised treatment options for CAH patients and thus to improve their quality of life.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 205: The Adrenal: Central Relay in Health and Disease
• Applicant Institution: Technische Universität Dresden
• Project Heads: Professorin Angela Hübner, Ph.D.; Privatdozentin Dr. Katrin Köhler, since 7/2021; Professorin Dr. Nicole Reisch