Development of sex-specific therapeutic approaches towards glucocorticoids-driven metabolic dysfunction (A09)

• Subject Area: Endocrinology, Diabetology, Metabolism
• Term: since 2017
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 314061271

Project A09 investigates sex-specific differences in adrenal glucocorticoid (GC) signaling, a key regulator of metabolism in human health and disease. While GCs act via the glucocorticoid receptor (GR) to control gene expression, we identified distinct gene and miRNA regulatory patterns between sexes, affecting cholesterol and glucose metabolism. In the next funding period, we will dissect the molecular mechanisms driving these sex-biased differences in GC signaling. Sex-specific miRNA inhibitors and GR cofactors will be evaluated as therapeutic approaches for cardiometabolic disorders.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 205: The Adrenal: Central Relay in Health and Disease
• Applicant Institution: Technische Universität Dresden
• Project Heads: Professor Dr. Stephan Herzig; Professorin Dr. Nina Henriette Uhlenhaut