Accelerometer-controlled adaptive deep brain stimulation in rat models of Parkinson’s disease to influence motor and non-motor behaviour (C04)

• Subject Area: Experimental Models for the Understanding of Nervous System Diseases ; Molecular and Cellular Neurology and Neuropathology
• Term: since 2017
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 299150580

Current research in the field of deep brain stimulation in Parkinson's disease focuses on the development of adaptive stimulation paradigms. In this project, we investigate accelerometer measurements as a tool for continuously quantifying symptom severity in rat models with more or less advanced motor symptoms. The measurements are input parameters to control adaptive deep brain stimulation algorithms, and their effects on motor and non-motor symptoms are investigated. Furthermore, we will focus on the influence of neuroinflammation as a putative factor influencing disease progression.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1270: ELectrically Active ImplaNts - ELAINE
• Applicant Institution: Universität Rostock
• Project Heads: Dr. Mareike Fauser, since 7/2021; Professor Dr. Alexander Storch