Role of DDX56 in GSK3β regulation during Wnt signaling (B01)

• Subject Area: Cell Biology ; Developmental Biology
• Term: since 2017
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 331351713

We have previously identified the DEAD-box RNA helicase DDX3 as a regulator of the Wnt/β-catenin network in embryonic development, where it stimulates Casein kinase 1 epsilon (CK1e). Our unpublished work indicates that other members of the 44 DEAD-box RNA helicases can also function as kinase regulators in Wnt signaling. Here we will focus on DDX56 and its role in GSK3β regulation during Wnt signaling in mammalian cells and in early Xenopus embryonic development.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1324: Mechanisms and functions of Wnt signaling
• Applicant Institution: Ruprecht-Karls-Universität Heidelberg
• Project Head: Professor Dr. Christof Niehrs, Ph.D.