Orchestration of stem- and EMT-like phenotypes by Wnt signaling (B06)

• Subject Area: Cell Biology
• Term: since 2017
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 331351713

This project addresses the role of canonical Wnt activity along the “lineage” of normal adult neural stem cells (NSCs) and malignant glioblastoma multiforme (GBM) cells. It capitalizes in the unique combination of single cell transcriptome profiling of TCF/Lef-reporter cells from human and mouse origin, in vivo and in vitro assays to tackle invasion, connectivity and stemness, and mathematical modeling to guide loss and gain of function studies aiming at generating intelligent regenerative and anti-cancer therapies.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1324: Mechanisms and functions of Wnt signaling
• Applicant Institution: Ruprecht-Karls-Universität Heidelberg
• Project Head: Professorin Dr. Ana Martin-Villalba