Mitochondrial heterogeneity in synapses (A05)

• Subject Area: Molecular Biology and Physiology of Neurons and Glial Cells ; Biophysics ; Cell Biology
• Term: since 2017
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 317475864

The exact functional implications of nucleoid presence in synaptic mitochondria remain poorly understood. We will systematically characterize presynaptic mitochondria with and without nucleoids, analyze mitochondrial mRNA localizations, and investigate the mechanisms promoting synaptic enrichment of nucleoid-containing mitochondria. Ultimately, we aim to understand and quantify the molecular mechanisms driving the structural and functional adaptation of mitochondria to the demands of their presynaptic environment.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1286: Quantitative Synaptology
• Applicant Institution: Georg-August-Universität Göttingen
• Project Head: Professor Dr. Stefan Jakobs