The role of post-translationally modified proteins in synaptic transmission (A08)

• Subject Area: Biochemistry ; Cell Biology
• Term: since 2017
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 317475864

Post-translational modifications of proteins play an essential part in the regulation of synaptic transmission. Phosphorylation and ubiquitination are involved in regulating protein-protein interactions during neurotransmitter release, synaptic-vesicle (SV) recycling, and synapse development and maintenance. In addition, the glycosylation of synaptic proteins may be especially relevant for neurodegenerative diseases and ageing. We focused on protein phosphorylation during the first funding period, and we will now enlarge our focus to cover both ubiquitination and glycosylation.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1286: Quantitative Synaptology
• Applicant Institution: Georg-August-Universität Göttingen
• Project Heads: Professor Dr. Reinhard Jahn, until 6/2021; Professor Dr. Henning Urlaub