Quantitative molecular physiology of calyceal synapses (B05)

• Subject Area: Molecular Biology and Physiology of Neurons and Glial Cells ; Biophysics
• Term: since 2017
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 317475864

Calyceal synapses transmit information at high rates, with sub-millisecond temporal precision. During the second funding period, we found convincing morphological evidence for monoaminergic innervation and revealed a positive modulation of synaptic transmission at the endbulb of Held synapse by exogenously added norepinephrine. We now plan to study synaptic modulation and integration by optogenetically recruiting norepinephrinergic varicosities and the glutamatergic presynaptic endbulbs of a given postsynaptic bushy cell, respectively.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1286: Quantitative Synaptology
• Applicant Institution: Georg-August-Universität Göttingen
• Project Head: Professor Dr. Tobias Moser