Identification of molecular mechanisms conferring resistance to oncolytic viruses in HCC and implications for successful HCC virotherapy (C07)

• Subject Area: Gastroenterology
• Term: from 2017 to 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 314905040

Project C07 (Lauer/Eggert; Identification of molecular mechanisms conferring resistance to oncolytic viruses in HCC and implications for successful HCC virotherapy) is a joint Tübingen/Hannover project setting out to systematically identify critical pathways and immunosuppressive cell lineages mediating resistance to virotherapy in inflammation-associated HCC. The project aims to therapeutically interfere with these resistance mechanisms and to engineer novel virotherapeutic vectors and optimized vector-derived induction of anti-tumorous T-cell response.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 209: Liver Cancer - New mechanistic and therapeutic concepts in a solid tumor model
• Applicant Institution: Ruprecht-Karls-Universität Heidelberg
• Project Heads: Dr. Tobias Eggert, until 10/2018; Professor Dr. Florian Kühnel, since 11/2018; Professor Dr. Ulrich M. Lauer