EXC 257:  NeuroCure - Towards a Better Outcome of Neurological Disorders

• Subject Area: Neurosciences
• Term: from 2007 to 2018
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 39052203

• Final Report Year: 2019

Final Report Abstract

Neurological and psychiatric disorders pose a massive burden to society, and our understanding of the underlying molecular and pathophysiological mechanisms is limited. At the same time, the translation, or transfer, of knowledge from basic research into clinical application has proven difficult. For this reason, NeuroCure has set out to narrow the current gap between basic and clinical neuroscience and thereby promote the development and application of new therapies and diagnostic tools. To achieve the critical mass for excellent research in the neurosciences, we appointed more than 25 outstanding scientists, including excellent female researchers and promising early career scientists. Their integration into the existing scientific environment was promoted by collaborative projects with a strong interdisciplinary and translational focus. In addition, visiting fellow programs enabled us to recruit many international experts, including Nobel Laureates, for research stays in Berlin. Excellent research is also driven by the development of new technologies. NeuroCure therefore established several technology platforms that provide state-of-the-art instruments and expertise, e. g. in the areas of imaging and automated behavioral analysis of animal models of various diseases. In addition, the NeuroCure Clinical Research Center, a fully equipped outpatient facility, provides full administrative and logistic support for high-quality clinical trials. Successful translation additionally requires a strong interdisciplinary mind-set. We therefore developed an international MSc/PhD program with a focus on interdisciplinary research and translation, combining comprehensive training with advice from experienced neuroscientists across disciplines. Moreover, in line with our commitment to advance equal opportunity within the Cluster and our partner institutions, NeuroCure promoted the recruitment of excellent female scientists to higher academic positions through diverse measures. Finally, in cooperation with the Charité and our partner institutions, we overcame institutional and administrative barriers and established the Einstein Center for Neurosciences Berlin. Through these extensive measures, NeuroCure has substantially strengthened collaborations between basic and clinical researchers. The success of the Cluster is documented by many high-impact publications and a significant increase in collaborative research grants in Berlin. In the future, we will continue to use this momentum to secure Berlin’s position at the forefront of translational neuroscience.

Link to the final report

https://doi.org/10.2314/KXP:1698804903

Publications

• Head-anchored whole-cell recordings in freely moving rats. Nat Protoc, 2009. 4:385-392
  Lee AK, Epsztein J, Brecht M
  
• Sip1 regulates sequential fate decisions by feedback signaling from postmitotic neurons to progenitors. Nat Neurosci, 2009. 12:1373-1380
  Seuntjens E, Nityanandam A, Miquelajauregui A, Debruyn J, Stryjewska A, Goebbels S, Nave KA, Huylebroeck D, Tarabykin V
  
• Synaptic PRG-1 modulates excitatory transmission via lipid phosphate-mediated signaling. Cell, 2009. 138:1222-1235
  Trimbuch T, Beed P, Vogt J, Schuchmann S, Maier N, Kintscher M, Breustedt J, Schuelke M, Streu N, Kieselmann O, Brunk I, Laube G, Strauss U, Battefeld A, Wende H, Birchmeier C, Wiese S, Sendtner M, Kawabe H, Kishimoto-Suga M, Brose N, Baumgart J, Geist B, Aoki J, Savaskan NE, Brauer AU, Chun J, Ninnemann O, Schmitz D, Nitsch R
  
• An embedded subnetwork of highly active neurons in the neocortex. Neuron, 2010. 68:1043-1050
  Yassin L, Benedetti BL, Jouhanneau JS, Wen JA, Poulet JF, Barth AL
  
• Impact of spikelets on hippocampal CA1 pyramidal cell activity during spatial exploration. Science, 2010. 327:474-477
  Epsztein J, Lee AK, Chorev E, Brecht M
  
• MutationTaster evaluates disease-causing potential of sequence alterations. Nat Methods, 2010. 7:575-576
  Schwarz JM, Rodelsperger C, Schuelke M, Seelow D
  
• Control of TH17 cells occurs in the small intestine. Nature, 2011. 475:514-518
  Esplugues E, Huber S, Gagliani N, Hauser AE, Town T, Wan YY, O’Connor W, Jr., Rongvaux A, Van Rooijen N, Haberman AM, Iwakura Y, Kuchroo VK, Kolls JK, Bluestone JA, Herold KC, Flavell RA
  
• RIM-binding protein, a central part of the active zone, is essential for neurotransmitter release. Science, 2011. 334:1565-1569
  Liu KS, Siebert M, Mertel S, Knoche E, Wegener S, Wichmann C, Matkovic T, Muhammad K, Depner H, Mettke C, Buckers J, Hell SW, Muller M, Davis GW, Schmitz D, Sigrist SJ
  
• Suppressing immunosuppression after stroke. N Engl J Med, 2011. 365:2134-2136
  Meisel C, Meisel A
  
• An unconventional role for miRNA: let-7 activates Toll-like receptor 7 and causes neurodegeneration. Nat Neurosci, 2012. 15:827-835
  Lehmann SM, Kruger C, Park B, Derkow K, Rosenberger K, Baumgart J, Trimbuch T, Eom G, Hinz M, Kaul D, Habbel P, Kalin R, Franzoni E, Rybak A, Nguyen D, Veh R, Ninnemann O, Peters O, Nitsch R, Heppner FL, Golenbock D, Schott E, Ploegh HL, Wulczyn FG, Lehnardt S
  
• Autistic-like behaviours and hyperactivity in mice lacking ProSAP1/Shank2. Nature, 2012. 486:256-260
  Schmeisser MJ, Ey E, Wegener S, Bockmann J, Stempel AV, Kuebler A, Janssen AL, Udvardi PT, Shiban E, Spilker C, Balschun D, Skryabin BV, Dieck S, Smalla KH, Montag D, Leblond CS, Faure P, Torquet N, Le Sourd AM, Toro R, Grabrucker AM, Shoichet SA, Schmitz D, Kreutz MR, Bourgeron T, Gundelfinger ED, Boeckers TM
  
• Cooperation of Syd-1 with Neurexin synchronizes pre- with postsynaptic assembly. Nat Neurosci, 2012. 15:1219-1226
  Owald D, Khorramshahi O, Gupta VK, Banovic D, Depner H, Fouquet W, Wichmann C, Mertel S, Eimer S, Reynolds E, Holt M, Aberle H, Sigrist SJ
  
• Coupled control of desensitization and gating by the ligand binding domain of glutamate receptors. Neuron, 2012. 74:845-857
  Carbone AL, Plested AJ
  
• Current research trends in early life stress and depression: review of human studies on sensitive periods, gene-environment interactions, and epigenetics. Exp Neurol, 2012. 233:102-111
  Heim C, Binder EB
  
• Essential role of interleukin-6 in post-stroke angiogenesis. Brain, 2012. 135:1964-1980
  Gertz K, Kronenberg G, Kalin RE, Baldinger T, Werner C, Balkaya M, Eom GD, Hellmann-Regen J, Krober J, Miller KR, Lindauer U, Laufs U, Dirnagl U, Heppner FL, Endres M
  
• Inhibition of IL-12/IL-23 signaling reduces Alzheimer’s disease-like pathology and cognitive decline. Nat Med, 2012. 18:1812-1819
  Vom Berg J, Prokop S, Miller KR, Obst J, Kalin RE, Lopategui-Cabezas I, Wegner A, Mair F, Schipke CG, Peters O, Winter Y, Becher B, Heppner FL
  
• Raising cytosolic Cl- in cerebellar granule cells affects their excitability and vestibulo-ocular learning. EMBO J, 2012. 31:1217-1230
  Seja P, Schonewille M, Spitzmaul G, Badura A, Klein I, Rudhard Y, Wisden W, Hubner CA, De Zeeuw CI, Jentsch TJ
  
• Segregation of axonal and somatic activity during fast network oscillations. Science, 2012. 336:1458-1461
  Dugladze T, Schmitz D, Whittington MA, Vida I, Gloveli T
  
• The cellular basis of GABA(B)-mediated interhemispheric inhibition. Science, 2012. 335:989-993
  Palmer LM, Schulz JM, Murphy SC, Ledergerber D, Murayama M, Larkum ME
  
• The transcription factor c-Maf controls touch receptor development and function. Science, 2012. 335:1373-1376
  Wende H, Lechner SG, Cheret C, Bourane S, Kolanczyk ME, Pattyn A, Reuter K, Munier FL, Carroll P, Lewin GR, Birchmeier C
  
• Association between childhood trauma and low hair cortisol in depressed patients and healthy control subjects. Biol Psychiatry, 2013. 74:e15-17
  Hinkelmann K, Muhtz C, Dettenborn L, Agorastos A, Wingenfeld K, Spitzer C, Gao W, Kirschbaum C, Wiedemann K, Otte C
  
• Functional and structural brain changes in anti-N-methyl-D- aspartate receptor encephalitis. Ann Neurol, 2013. 74:284-296
  Finke C, Kopp UA, Scheel M, Pech LM, Soemmer C, Schlichting J, Leypoldt F, Brandt AU, Wuerfel J, Probst C, Ploner CJ, Pruss H, Paul F
  
• Identifying the perfusion deficit in acute stroke with resting-state functional magnetic resonance imaging. Ann Neurol, 2013. 73:136-140
  Lv Y, Margulies DS, Cameron Craddock R, Long X, Winter B, Gierhake D, Endres M, Villringer K, Fiebach J, Villringer A
  
• Immunoproteasomes are important for proteostasis in immune responses. Cell, 2013. 152:935-937
  Ebstein F, Voigt A, Lange N, Warnatsch A, Schroter F, Prozorovski T, Kuckelkorn U, Aktas O, Seifert U, Kloetzel PM, Kruger E
  
• Restoring polyamines protects from age-induced memory impairment in an autophagydependent manner. Nat Neurosci, 2013. 16:1453-1460
  Gupta VK, Scheunemann L, Eisenberg T, Mertel S, Bhukel A, Koemans TS, Kramer JM, Liu KS, Schroeder S, Stunnenberg HG, Sinner F, Magnes C, Pieber TR, Dipt S, Fiala A, Schenck A, Schwaerzel M, Madeo F, Sigrist SJ
  
• Spatiotemporal control of endocytosis by phosphatidylinositol-3,4-bisphosphate. Nature, 2013. 499:233-237
  Posor Y, Eichhorn-Gruenig M, Puchkov D, Schoneberg J, Ullrich A, Lampe A, Muller R, Zarbakhsh S, Gulluni F, Hirsch E, Krauss M, Schultz C, Schmoranzer J, Noe F, Haucke V
  
• Sugar for the brain: the role of glucose in physiological and pathological brain function. Trends Neurosci, 2013. 36:587-597
  Mergenthaler P, Lindauer U, Dienel GA, Meisel A
  
• Ultrafast endocytosis at mouse hippocampal synapses. Nature, 2013. 504:242
  Watanabe S, Rost BR, Camacho-Perez M, Davis MW, Sohl-Kielczynski B, Rosenmund C, Jorgensen EM
  
• Clathrin regenerates synaptic vesicles from endosomes. Nature, 2014. 515:228-233
  Watanabe S, Trimbuch T, Camacho-Perez M, Rost BR, Brokowski B, Sohl-Kielczynski B, Felies A, Davis MW, Rosenmund C, Jorgensen EM
  
• Cortical fosGFP expression reveals broad receptive field excitatory neurons targeted by POm. Neuron, 2014. 84:1065-1078
  Jouhanneau JS, Ferrarese L, Estebanez L, Audette NJ, Brecht M, Barth AL, Poulet JF
  
• Deep brain stimulation suppresses pallidal low frequency activity in patients with phasic dystonic movements. Brain, 2014. 137:3012-3024
  Barow E, Neumann WJ, Brucke C, Huebl J, Horn A, Brown P, Krauss JK, Schneider GH, Kuhn AA
  
• Different patterns of local field potentials from limbic DBS targets in patients with major depressive and obsessive compulsive disorder. Mol Psychiatry, 2014. 19:1186-1192
  Neumann WJ, Huebl J, Brucke C, Gabriels L, Bajbouj M, Merkl A, Schneider GH, Nuttin B, Brown P, Kuhn AA
  
• Effect of the use of ambulance-based thrombolysis on time to thrombolysis in acute ischemic stroke: a randomized clinical trial. JAMA, 2014. 311:1622-1631
  Ebinger M, Winter B, Wendt M, Weber JE, Waldschmidt C, Rozanski M, Kunz A, Koch P, Kellner PA, Gierhake D, Villringer K, Fiebach JB, Grittner U, Hartmann A, Mackert BM, Endres M, Audebert HJ; STEMO Consortium
  
• Grid-layout and theta-modulation of layer 2 pyramidal neurons in medial entorhinal cortex. Science, 2014. 343:891-896
  Ray S, Naumann R, Burgalossi A, Tang Q, Schmidt H, Brecht M
  
• Identification of LRRC8 heteromers as an essential component of the volume-regulated anion channel VRAC. Science, 2014. 344:634-638
  Voss FK, Ullrich F, Munch J, Lazarow K, Lutter D, Mah N, Andrade-Navarro MA, von Kries JP, Stauber T, Jentsch TJ
  
• MutationTaster2: mutation prediction for the deepsequencing age. Nat Methods, 2014. 11:361-362
  Schwarz JM, Cooper DN, Schuelke M, Seelow D
  
• Photoinactivation of glutamate receptors by genetically encoded unnatural amino acids. J Neurosci, 2014. 34:980-991
  Klippenstein V, Ghisi V, Wietstruk M, Plested AJ
  
• Regulation of the mammalian elongation cycle by subunit rolling: a eukaryotic-specific ribosome rearrangement. Cell, 2014. 158:121-131
  Budkevich TV, Giesebrecht J, Behrmann E, Loerke J, Ramrath DJ, Mielke T, Ismer J, Hildebrand PW, Tung CS, Nierhaus KH, Sanbonmatsu KY, Spahn CM
  
• Beyond Molecular Codes: Simple Rules to Wire Complex Brains. Cell, 2015. 163:285-291
  Hassan BA, Hiesinger PR
  
• Functional Diversity of Subicular Principal Cells during Hippocampal Ripples. J Neurosci, 2015. 35:13608-13618
  Bohm C, Peng Y, Maier N, Winterer J, Poulet JF, Geiger JR, Schmitz D
  
• Immune attack: the role of inflammation in Alzheimer disease. Nat Rev Neurosci, 2015. 16:358-372
  Heppner FL, Ransohoff RM, Becher B
  
• Impact of peripheral myeloid cells on amyloid-beta pathology in Alzheimer’s disease-like mice. J Exp Med, 2015. 212:1811-1818
  Prokop S, Miller KR, Drost N, Handrick S, Mathur V, Luo J, Wegner A, Wyss-Coray T, Heppner FL
  
• Optogenetic acidification of synaptic vesicles and lysosomes. Nat Neurosci, 2015. 18:1845-1852
  Rost BR, Schneider F, Grauel MK, Wozny C, Bentz C, Blessing A, Rosenmund T, Jentsch TJ, Schmitz D, Hegemann P, Rosenmund C
  
• Presynaptic spinophilin tunes neurexin signalling to control active zone architecture and function. Nat Commun, 2015. 6:8362
  Muhammad K, Reddy-Alla S, Driller JH, Schreiner D, Rey U, Bohme MA, Hollmann C, Ramesh N, Depner H, Lutzkendorf J, Matkovic T, Gotz T, Bergeron DD, Schmoranzer J, Goettfert F, Holt M, Wahl MC, Hell SW, Scheiffele P, Walter AM, Loll B, Sigrist SJ
  
• Prevention of stroke-associated pneumonia: where next? Lancet, 2015. 386:1802-1804
  Meisel A, Smith CJ
  
• Proteotoxic stress and ageing triggers the loss of redox homeostasis across cellular compartments. EMBO J, 2015. 34:2334-2349
  Kirstein J, Morito D, Kakihana T, Sugihara M, Minnen A, Hipp MS, Nussbaum-Krammer C, Kasturi P, Hartl FU, Nagata K, Morimoto RI
  
• Robust research: Institutions must do their part for reproducibility. Nature, 2015. 525:25-27
  Begley CG, Buchan AM, Dirnagl U
  
• Structural snapshots of actively translating human ribosomes. Cell, 2015. 161:845-857
  Behrmann E, Loerke J, Budkevich TV, Yamamoto K, Schmidt A, Penczek PA, Vos MR, Burger J, Mielke T, Scheerer P, Spahn CM
  
• The Developmental Rules of Neural Superposition in Drosophila. Cell, 2015. 162:120-133
  Langen M, Agi E, Altschuler DJ, Wu LF, Altschuler SJ, Hiesinger PR
  
• Tracking CNS and systemic sources of oxidative stress during the course of chronic neuroinflammation. Acta Neuropathol, 2015. 130:799-814
  Mossakowski AA, Pohlan J, Bremer D, Lindquist R, Millward JM, Bock M, Pollok K, Mothes R, Viohl L, Radbruch M, Gerhard J, Bellmann-Strobl J, Behrens J, Infante-Duarte C, Mahler A, Boschmann M, Rinnenthal JL, Fuchtemeier M, Herz J, Pache FC, Bardua M, Priller J, Hauser AE, Paul F, Niesner R, Radbruch H
  
• Active zone scaffolds differentially accumulate Unc13 isoforms to tune Ca(2+) channel-vesicle coupling. Nat Neurosci, 2016. 19:1311-1320
  Bohme MA, Beis C, Reddy-Alla S, Reynolds E, Mampell MM, Grasskamp AT, Lutzkendorf J, Bergeron DD, Driller JH, Babikir H, Gottfert F, Robinson IM, O’Kane CJ, Hell SW, Wahl MC, Stelzl U, Loll B, Walter AM, Sigrist SJ
  
• Autophagosome Formation by Endophilin Keeps Synapses in Shape. Neuron, 2016. 92:675-677
  Kuijpers M, Haucke V
  
• Brain networks modulated by subthalamic nucleus deep brain stimulation. Brain, 2016. 139:2503-2515
  Accolla EA, Herrojo Ruiz M, Horn A, Schneider GH, Schmitz-Hubsch T, Draganski B, Kuhn AA
  
• Disruption of Kcc2-dependent inhibition of olfactory bulb output neurons suggests its importance in odour discrimination. Nat Commun, 2016. 7:12043
  Godde K, Gschwend O, Puchkov D, Pfeffer CK, Carleton A, Jentsch TJ
  
• High-fat diet-induced brain region-specific phenotypic spectrum of CNS resident microglia. Acta Neuropathol, 2016. 132:361-375
  Baufeld C, Osterloh A, Prokop S, Miller KR, Heppner FL
  
• Loss of MeCP2 disrupts cell autonomous and autocrine BDNF signaling in mouse glutamatergic neurons. Elife, 2016. 5:e19374
  Sampathkumar C, Wu YJ, Vadhvani M, Trimbuch T, Eickholt B, Rosenmund C
  
• Mutations in Subunits of the Activating Signal Cointegrator 1 Complex Are Associated with Prenatal Spinal Muscular Atrophy and Congenital Bone Fractures. Am J Hum Genet, 2016. 98:473-489
  Knierim E, Hirata H, Wolf NI, Morales-Gonzalez S, Schottmann G, Tanaka Y, Rudnik-Schoneborn S, Orgeur M, Zerres K, Vogt S, van Riesen A, Gill E, Seifert F, Zwirner A, Kirschner J, Goebel HH, Hubner C, Stricker S, Meierhofer D, Stenzel W, Schuelke M
  
• Neural correlates of ticklishness in the rat somatosensory cortex. Science, 2016. 354:757-760
  Ishiyama S, Brecht M
  
• Resident microglia rather than peripheral macrophages promote vascularization in brain tumors and are source of alternative pro-angiogenic factors. Acta Neuropathol, 2016. 131:365-378
  Brandenburg S, Muller A, Turkowski K, Radev YT, Rot S, Schmidt C, Bungert AD, Acker G, Schorr A, Hippe A, Miller K, Heppner FL, Homey B, Vajkoczy P
  
• RIM-binding protein 2 regulates release probability by fine-tuning calcium channel localization at murine hippocampal synapses. Proc Natl Acad Sci USA, 2016. 113:11615-11620
  Grauel MK, Maglione M, Reddy-Alla S, Willmes CG, Brockmann MM, Trimbuch T, Rosenmund T, Pangalos M, Vardar G, Stumpf A, Walter AM, Rost BR, Eickholt BJ, Haucke V, Schmitz D, Sigrist SJ, Rosenmund C
  
• Scattering compensation by focus scanning holographic aberration probing (F-SHARP). Nature Photonics, 2016. 11:116-123
  Papadopoulos IN, Jouhanneau J-S, Poulet JFA, Judkewitz B
  
• Spermidine Suppresses Age-Associated Memory Impairment by Preventing Adverse Increase of Presynaptic Active Zone Size and Release. PLoS Biol, 2016. 14:e1002563
  Gupta VK, Pech U, Bhukel A, Fulterer A, Ender A, Mauermann SF, Andlauer TF, Antwi-Adjei E, Beuschel C, Thriene K, Maglione M, Quentin C, Bushow R, Schwarzel M, Mielke T, Madeo F, Dengjel J, Fiala A, Sigrist SJ
  
• Structural Hippocampal Damage Following Anti-N-Methyl-D-Aspartate Receptor Encephalitis. Biol Psychiatry, 2016. 79:727-734
  Finke C, Kopp UA, Pajkert A, Behrens JR, Leypoldt F, Wuerfel JT, Ploner CJ, Pruss H, Paul F
  
• Superactivation of AMPA receptors by auxiliary proteins. Nat Commun, 2016. 7:10178
  Carbone AL, Plested AJ
  
• The role of microglia and macrophages in glioma maintenance and progression. Nat Neurosci, 2016. 19:20-27
  Hambardzumyan D, Gutmann DH, Kettenmann H
  
• Where Have All the Rodents Gone? The Effects of Attrition in Experimental Research on Cancer and Stroke. PLoS Biol, 2016. 14:e1002331
  Holman C, Piper SK, Grittner U, Diamantaras AA, Kimmelman J, Siegerink B, Dirnagl U
  
• Bortezomib for treatment of therapy-refractory anti-NMDA receptor encephalitis. Neurology, 2017. 88:366-370
  Scheibe F, Pruss H, Mengel AM, Kohler S, Numann A, Kohnlein M, Ruprecht K, Alexander T, Hiepe F, Meisel A
  
• Cognition-mediated evolution of low-quality floral nectars. Science, 2017. 355:75-78
  Nachev V, Stich KP, Winter C, Bond A, Kamil A, Winter Y
  
• Control of AMPA receptor activity by the extracellular loops of auxiliary proteins. Elife, 2017. 6:e28680
  Riva I, Eibl C, Volkmer R, Carbone AL, Plested AJ
  
• Cortical dendritic activity correlates with spindle-rich oscillations during sleep in rodents. Nat Commun, 2017. 8:684
  Seibt J, Richard CJ, Sigl-Glockner J, Takahashi N, Kaplan DI, Doron G, de Limoges D, Bocklisch C, Larkum ME
  
• Dendritic calcium spikes are clearly detectable at the cortical surface. Nat Commun, 2017. 8:276
  Suzuki M, Larkum ME
  
• Fructosedriven glycolysis supports anoxia resistance in the naked mole-rat. Science, 2017. 356:307-311
  Park TJ, Reznick J, Peterson BL, Blass G, Omerbasic D, Bennett NC, Kuich P, Zasada C, Browe BM, Hamann W, Applegate DT, Radke MH, Kosten T, Lutermann H, Gavaghan V, Eigenbrod O, Begay V, Amoroso VG, Govind V, Minshall RD, Smith ESJ, Larson J, Gotthardt M, Kempa S, Lewin GR
  
• Heterodimerization of Munc13 C2A domain with RIM regulates synaptic vesicle docking and priming. Nat Commun, 2017. 8:15293
  Camacho M, Basu J, Trimbuch T, Chang S, Pulido-Lozano C, Chang SS, Duluvova I, Abo-Rady M, Rizo J, Rosenmund C
  
• Layer-Specific Organization of Local Excitatory and Inhibitory Synaptic Connectivity in the Rat Presubiculum. Cereb Cortex, 2017. 27:2435-2452
  Peng Y, Barreda Tomas FJ, Klisch C, Vida I, Geiger JRP
  
• Loss of a mammalian circular RNA locus causes miRNA deregulation and affects brain function. Science, 2017. 357
  Piwecka M, Glazar P, Hernandez-Miranda LR, Memczak S, Wolf SA, Rybak-Wolf A, Filipchyk A, Klironomos F, Cerda Jara CA, Fenske P, Trimbuch T, Zywitza V, Plass M, Schreyer L, Ayoub S, Kocks C, Kuhn R, Rosenmund C, Birchmeier C, Rajewsky N
  
• mTORC1 activity repression by late endosomal phosphatidylinositol 3,4-bisphosphate. Science, 2017. 356:968-972
  Marat AL, Wallroth A, Lo WT, Muller R, Norata GD, Falasca M, Schultz C, Haucke V
  
• Patrolling monocytes sense peripheral infection and induce cytokine-mediated neuronal dysfunction. Nat Med, 2017. 23:659-661
  Priller J, Bottcher C
  
• Retrograde transport of TrkB-containing autophagosomes via the adaptor AP-2 mediates neuronal complexity and prevents neurodegeneration. Nat Commun, 2017. 8:14819
  Kononenko NL, Classen GA, Kuijpers M, Puchkov D, Maritzen T, Tempes A, Malik AR, Skalecka A, Bera S, Jaworski J, Haucke V
  
• Stroke-induced immunodepression and dysphagia independently predict stroke-associated pneumonia - The PREDICT study. J Cereb Blood Flow Metab, 2017. 37:3671-3682
  Hoffmann S, Harms H, Ulm L, Nabavi DG, Mackert BM, Schmehl I, Jungehulsing GJ, Montaner J, Bustamante A, Hermans M, Hamilton F, Gohler J, Malzahn U, Malsch C, Heuschmann PU, Meisel C, Meisel A, PREDICT Investigators
  
• When Habits Are Dangerous: Alcohol Expectancies and Habitual Decision Making Predict Relapse in Alcohol Dependence. Biol Psychiatry, 2017. 82:847-856
  Sebold M, Nebe S, Garbusow M, Guggenmos M, Schad DJ, Beck A, Kuitunen-Paul S, Sommer C, Frank R, Neu P, Zimmermann US, Rapp MA, Smolka MN, Huys QJM, Schlagenhauf F, Heinz A
  
• Complete suppression of Htt fibrilization and disaggregation of Htt fibrils by a trimeric chaperone complex. EMBO J, 2018. 37:282-299
  Scior A, Buntru A, Arnsburg K, Ast A, Iburg M, Juenemann K, Pigazzini ML, Mlody B, Puchkov D, Priller J, Wanker EE, Prigione A, Kirstein J
  
• Cortical specialization for attended versus unattended working memory. Nat Neurosci, 2018. 21:494-496
  Christophel TB, Iamshchinina P, Yan C, Allefeld C, Haynes JD
  
• mHTT Seeding Activity: A Marker of Disease Progression and Neurotoxicity in Models of Huntington’s Disease. Mol Cell, 2018. 71:675-688 e676
  Ast A, Buntru A, Schindler F, Hasenkopf R, Schulz A, Brusendorf L, Klockmeier K, Grelle G, McMahon B, Niederlechner H, Jansen I, Diez L, Edel J, Boeddrich A, Franklin SA, Baldo B, Schnoegl S, Kunz S, Purfurst B, Gaertner A, Kampinga HH, Morton AJ, Petersen A, Kirstein J, Bates GP, Wanker EE
  
• Neuregulin 3 promotes excitatory synapse formation on hippocampal interneurons. EMBO J, 2018. 37
  Muller T, Braud S, Juttner R, Voigt BC, Paulick K, Sheean ME, Klisch C, Gueneykaya D, Rathjen FG, Geiger JR, Poulet JF, Birchmeier C
  
• Potassium channel-based optogenetic silencing. Nat Commun, 2018. 9:4611
  Bernal Sierra YA, Rost BR, Pofahl M, Fernandes AM, Kopton RA, Moser S, Holtkamp D, Masala N, Beed P, Tukker JJ, Oldani S, Bonigk W, Kohl P, Baier H, Schneider-Warme F, Hegemann P, Beck H, Seifert R, Schmitz D
  
• Scattering correlations of time-gated light. Optica, 2018. 5:389-394
  Kadobianskyi M, Papadopoulos IN, Chaigne T, Horstmeyer R, Judkewitz B
  
• Single synaptic inputs drive high-precision action potentials in parvalbumin expressing GABA-ergic cortical neurons in vivo. Nat Commun, 2018. 9:1540
  Jouhanneau JS, Kremkow J, Poulet JFA
  
• Synaptotagmin-1 drives synchronous Ca(2+)-triggered fusion by C2B-domain-mediated synaptic-vesicle-membrane attachment. Nat Neurosci, 2018. 21:33-40
  Chang S, Trimbuch T, Rosenmund C
  
• The neural circuits of thermal perception. Curr Opin Neurobiol, 2018. 52:98-106
  Bokiniec P, Zampieri N, Lewin GR, Poulet JF
  
• ATM phosphorylation of the actin-binding protein drebrin controls oxidation stress-resistance in mammalian neurons and C. elegans. Nat Commun, 2019. 10:486
  Kreis P, Gallrein C, Rojas-Puente E, Mack TGA, Kroon C, Dinkel V, Willmes C, Murk K, Tom-Dieck S, Schuman EM, Kirstein J, Eickholt BJ
  
• Differential Dependence of GABAergic and Glutamatergic Neurons on Glia for the Establishment of Synaptic Transmission. Cereb Cortex, 2019. 29:1230-1243
  Turko P, Groberman K, Browa F, Cobb S, Vida I
  
• Effects of spermidine supplementation on cognition and biomarkers in older adults with subjective cognitive decline (SmartAge)-study protocol for a randomized controlled trial. Alzheimers Res Ther, 2019. 11:36
  Wirth M, Schwarz C, Benson G, Horn N, Buchert R, Lange C, Kobe T, Hetzer S, Maglione M, Michael E, Marschenz S, Mai K, Kopp U, Schmitz D, Grittner U, Sigrist SJ, Stekovic S, Madeo F, Floel A
  
• Human gestational N-methyl-d-aspartate receptor autoantibodies impair neonatal murine brain function. Ann Neurol, 2019. 86:656-670
  Jurek B, Chayka M, Kreye J, Lang K, Kraus L, Fidzinski P, Kornau HC, Dao LM, Wenke NK, Long M, Rivalan M, Winter Y, Leubner J, Herken J, Mayer S, Mueller S, Boehm-Sturm P, Dirnagl U, Schmitz D, Kolch M, Pruss H
  
• Human microglia regional heterogeneity and phenotypes determined by multiplexed single-cell mass cytometry. Nat Neurosci, 2019. 22:78-90
  Bottcher C, Schlickeiser S, Sneeboer MAM, Kunkel D, Knop A, Paza E, Fidzinski P, Kraus L, Snijders GJL, Kahn RS, Schulz AR, Mei HE, Psy NBB, Hol EM, Siegmund B, Glauben R, Spruth EJ, de Witte LD, Priller J
  
• Intramolecular domain dynamics regulate synaptic MAGUK protein interactions. Elife, 2019. 8
  Rademacher N, Kuropka B, Kunde SA, Wahl MC, Freund C, Shoichet SA
  
• Physical Fitness Training in Patients with Subacute Stroke (PHYS-STROKE): multicentre, randomised controlled, endpoint blinded trial. BMJ, 2019. 366:l5101
  Nave AH, Rackoll T, Grittner U, Blasing H, Gorsler A, Nabavi DG, Audebert HJ, Klostermann F, Muller- Werdan U, Steinhagen-Thiessen E, Meisel A, Endres M, Hesse S, Ebinger M, Floel A
  
• Rapid molecular evolution of pain insensitivity in multiple African rodents. Science, 2019. 364:852-859
  Eigenbrod O, Debus KY, Reznick J, Bennett NC, Sanchez-Carranza O, Omerbasic D, Hart DW, Barker AJ, Zhong W, Lutermann H, Katandukila JV, Mgode G, Park TJ, Lewin GR
  
• Rethinking research reproducibility. EMBO J, 2019. 38
  Dirnagl U
  
• RIM-BP2 primes synaptic vesicles via recruitment of Munc13-1 at hippocampal mossy fiber synapses. Elife, 2019. 8
  Brockmann MM, Maglione M, Willmes CG, Stumpf A, Bouazza BA, Velasquez LM, Grauel MK, Beed P, Lehmann M, Gimber N, Schmoranzer J, Sigrist SJ, Rosenmund C, Schmitz D
  
• Single Synapse Indicators of Impaired Glutamate Clearance Derived from Fast iGlu u Imaging of Cortical Afferents in the Striatum of Normal and Huntington (Q175) Mice. J Neurosci, 2019. 39:3970-3982
  Dvorzhak A, Helassa N, Torok K, Schmitz D, Grantyn R