GSC 226: Göttinger Graduiertenschule für Neurowissenschaften, Biophysik und Molekulare Biowissenschaften
Neurowissenschaften
Zusammenfassung der Projektergebnisse
Das im Jahr 2007 gegründete Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften wurde 2018 als eine dauerhafte interdisziplinäre wissenschaftliche Einrichtung der Universität Göttingen eingerichtet. Es wird gemeinsam getragen von den Fakultäten für Biologie & Psychologie, Chemie und Physik, der Universitätsmedizin Göttingen, dem Deutschen Primatenzentrum und drei lokalen Max-Planck-Instituten. Alle ProfessorInnen und NachwuchsgruppenleiterInnen haben unabhängig von ihrer institutionellen Zugehörigkeit dieselben Prüfungsrechte und können Promovierende betreuen. Seit seiner Gründung hat das GGNB mit aktuell 15 Promotionsprogrammen nicht nur unter seinen Mitgliedern eine gemeinsame Identität geschaffen, sondern auch großen Einfluss auf die wissenschaftliche Entwicklung der mitwirkenden Institutionen, die Initiierung gemeinsamer Forschungskollaborationen, Neuberufungen sowie die Integration von Wissenschaftseinrichtungen über institutionelle Grenzen hinweg gehabt. Das Hauptziel des GGNB ist die Förderung von Exzellenz durch Training und Betreuung von Promovierenden in den Lebenswissenschaften, welche auf einer Tradition interdisziplinärer Kooperation zwischen international anerkannten Wissenschaftlern und gemeinsamer individueller Betreuung aufbaut. Das GGNB bietet eine bestmögliche Ausbildung und berufliche Entwicklung durch strukturierte Unterstützung, wissenschaftliche Qualifikation höchster Qualität und einen umfassenden Karriereservice auch für PostdoktorandInnen und fördert wissenschaftliche Netzwerke seiner aktuellen und früheren Mitglieder. Am sichtbarsten wird dieses erreichte Ausmaß an Zusammenarbeit durch die beeindruckende Anzahl gemeinsamer Publikationen von GGNB-WissenschaftlerInnen. Das GGNB hat inzwischen alle seine wichtigsten Ziele erreicht wie z.B. Qualitätssicherung durch Panel-basierte Aufnahme seiner Promovierenden, ein umfassendes Qualifikationsprogramm mit Wahlfreiheit für maßgeschneiderte Curricula, enge Betreuung durch Betreuungsausschüsse (drei unabhängige DozentInnen, Betreuungsvereinbarung, regelmäßige Treffen und Berichte), sowie strukturierte Unterstützung der Karriereentwicklung und von Alumni-Netzwerken. Die durchschnittliche Promotionsdauer bis zur Dissertationsabgabe liegt bei 3,6 Jahren, die Abbruchquote bei 4%. Im Rahmen der Umwandlung in ein dauerhaftes Graduiertenzentrum hat das GGNB sich enger mit der Georg-August University School of Science (GAUSS) zusammengeschlossen, der Dachorganisation aller mathematisch-naturwissenschaftlich Promovierenden. Die geänderte GAUSS-weite Promotionsordnung definiert neue gemeinsame Standards. Die meisten Elemente des GGNB-Qualifikationsprogramms wurden mit Maßnahmen anderer GAUSS-Programme zusammengeführt. Der GAUSS-weite Career Service für PostdoktorandInnen und Promovierende in der Spätphase ihrer Doktorarbeit übernimmt nicht nur die Unterstützung von NachwuchswissenschaftlerInnen, sondern fördert auch die Alumni Netzwerke.
Link zum Abschlussbericht
https://doi.org/10.2314/KXP:1698964048
Projektbezogene Publikationen (Auswahl)
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(2010) A role for Rho GTPases and cell-cell adhesion in single-cell motility in vivo. Nat Cell Biol 12(1):47
Kardash E, Reichman-Fried M, Maitre J, Boldajipour B, Papusheva E, Messerschmidt E, Heisenberg C, Raz E
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(2010) Altered Histone Acetylation Is Associated with Age-Dependent Memory Impairment in Mice. Science 328(5979):753-756
Peleg S, Sananbenesi F, Zovoilis A, Burkhardt S, Bahari-Javan S, Agis-Balboa R, Cota P, Wittnam J, Gogol-Doering A, Opitz L, Salinas-Riester G, Dettenhofer M, Kang H, Farinelli L, Chen W, Fischer A
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(2010) Crystal structure of an intramolecular chaperone mediating triple-beta-helix folding. Nat Struct Mol Biol 17(2):210
Schulz E, Dickmanns A, Urlaub H, Schmitt A, Muehlenhoff M, Stummeyer K, Schwarzer D, Gerardy- Schahn R, Ficner R
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(2010) Human PRP4 kinase is required for stable tri-snRNP association during spliceosomal B complex formation. Nat Struct Mol Biol 17(2):216
Schneider M, Hsiao H, Will C, Giet R, Urlaub H, Luehrmann R
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(2010) NES consensus redefined by structures of PKI-type and Rev-type nuclear export signals bound to CRM1. Nat Struct Mol Biol 17(11):1367
Guettler T, Madl T, Neumann P, Deichsel D, Corsini L, Monecke T, Ficner R, Sattler M, Goerlich D
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(2010) Olfactory Coding with Patterns of Response Latencies. Neuron 67(5):872-884
Junek S, Kludt E, Wolf F, Schild D
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(2010) SNARE Protein Recycling by alpha SNAP and beta SNAP Supports Synaptic Vesicle Priming. Neuron 68(3):473-487
Burgalossi A, Jung S, Meyer G, Jockusch W, Jahn O, Taschenberger H, O′Connor V, Nishiki T, Takahashi M, Brose N, Rhee J
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(2011) A readily retrievable pool of synaptic vesicles. Nat Neurosci 14(7):833-9
Hua Y, Sinha R, Thiel CS, Schmidt R, Hüve J, Martens H, Hell SW, Egner A, Klingauf J
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(2011) A reversibly photoswitchable GFP-like protein with fluorescence excitation decoupled from switching. Nat Biotechnol 29(10):942
Brakemann T, Stiel A, Weber G, Andresen M, Testa I, Grotjohann T, Leutenegger M, Plessmann U, Urlaub H, Eggeling C, Wahl M, Hell S, Jakobs S
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(2011) A Size Barrier Limits Protein Diffusion at the Cell Surface to Generate Lipid-Rich Myelin-Membrane Sheets. Dev Cell 21(3):445-456
Aggarwal S, Yurlova L, Snaidero N, Reetz C, Frey S, Zimmermann J, Paehler G, Janshoff A, Friedrichs J, Mueller D, Goebel C, Simons M
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(2011) Choosing Goals, Not Rules: Deciding among Rule-Based Action Plans. Neuron 70(3):536-548
Klaes C, Westendorff S, Chakrabarti S, Gail A
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(2011) Diffraction-unlimited all-optical imaging and writing with a photochromic GFP. Nature 478(7368):204-208
Grotjohann T, Testa I, Leutenegger M, Bock H, Urban N, Lavoie-Cardinal F, Willig K, Eggeling C, Jakobs S, Hell S
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(2011) Kinetics of Conformational Sampling in Ubiquitin. Angew Chem, Int Ed 50(48):11437-11440
Ban D, Funk M, Gulich R, Egger D, Sabo T, Walter K, Fenwick R, Giller K, Pichierri F, de Groot B, Lange O, Grubmueller H, Salvatella X, Wolf M, Loidl A, Kree R, Becker S, Lakomek N, Lee D, Lunkenheimer P, Griesinger C
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(2012) Direct gating and mechanical integrity of Drosophila auditory transducers require TRPN1. Nat Neurosci 15(9):1198
Effertz T, Nadrowski B, Piepenbrock D, Albert J, Goepfert M
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(2012) Drosophila Auditory Organ Genes and Genetic Hearing Defects. Cell 150(5):1042-1054
Senthilan P, Piepenbrock D, Ovezmyradov G, Nadrowski B, Bechstedt S, Pauls S, Winkler M, Moebius W, Howard J, Goepfert M
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(2012) Functional Neuroimaging and Transcranial Electrical Stimulation. Dev Cell 43(3):200-208
Turi Z, Paulus W, Antal A
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(2012) Membrane Fusion Intermediates via Directional and Full Assembly of the SNARE Complex. Science 336(6088):1581-1584
Hernandez J, Stein A, Behrmann E, Riedel D, Cypionka A, Farsi Z, Walla P, Raunser S, Jahn R
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(2012) Nanoscopy in a Living Mouse Brain. Science 335(6068):551-551
Berning S, Willig K, Steffens H, Dibaj P, Hell S
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(2012) Response to Comment on "Universality in the Evolution of Orientation Columns in the Visual Cortex. Science 336( 6080):413
Keil W, Kaschube M, Schnabel M, Kisvarday Z, Loewel S, Coppola D, White L, Wolf F
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(2012) The Histone H2B Monoubiquitination Regulatory Pathway Is Required for Differentiation of Multipotent Stem Cells. Mol Cell 46(5):705-713
Karpiuk O, Najafova Z, Kramer F, Hennion M, Galonska C, Koenig A, Snaidero N, Vogel T, Shchebet A, Begus-Nahrmann Y, Kassem M, Simons M, Shcherbata H, Beissbarth T, Johnsen S
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(2012) The Permeability of Reconstituted Nuclear Pores Provides Direct Evidence for the Selective Phase Model. Cell 150(4):738-751
Huelsmann B, Labokha A, Goerlich D
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(2012) The Prp8 RNase H-like domain inhibits Brr2-mediated U4/U6 snRNA unwinding by blocking Brr2 loading onto the U4 snRNA. Genes Dev 26(21):2422-2434
Mozaffari Jovin S, Santos K, Hsiao H, Will C, Urlaub H, Wahl M, Luehrmann R
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(2013) Blocking Endocytosis Enhances Short-Term Synaptic Depression under Conditions of Normal Availability of Vesicles. Neuron 80(2):343-349
Hua Y, Woehler A, Kahms M, Haucke V, Neher E, Klingauf J
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(2013) Combinatorial Nucleoside-Deletion-Scanning Mutagenesis of Functional DNA. Angew Chem, Int Ed 52(10):2995-2999
Samanta B, Hoebartner C
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(2013) EF-P Is Essential for Rapid Synthesis of Proteins Containing Consecutive Proline Residues. Science 339(6115):85-88
Doerfel L, Wohlgemuth I, Kothe C, Peske F, Urlaub H, Rodnina M
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(2013) Energy barriers and driving forces in tRNA translocation through the ribosome. Nat Struct Mol Biol 20(12):1390-1396
Bock L, Blau C, Schroeder G, Davydov I, Fischer N, Stark H, Rodnina M, Vaiana A, Grubmueller H
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(2013) Inhibition of RNA Helicase Brr2 by the C-Terminal Tail of the Spliceosomal Protein Prp8. Science 341(6141):80-84
Mozaffari-Jovin S, Wandersleben T, Santos K, Will C, Luehrmann R, Wahl M
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(2013) Molecular Profiling of Synaptic Vesicle Docking Sites Reveals Novel Proteins but Few Differences between Glutamatergic and GABAergic Synapses. Neuron 78(2):285-297
Boyken J, Gronborg M, Riedel D, Urlaub H, Jahn R, Chua J
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(2013) N-H Spin-Spin Couplings: Probing Hydrogen Bonds in Proteins. Angew Chem, Int Ed 52(12):3525-3528
Xiang S, Narayanan R, Becker S, Zweckstetter M
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(2013) SCFFbxw5 mediates transient degradation of actin remodeller Eps8 to allow proper mitotic progression. Nat Cell Biol 15(2):179-188
Werner A, Disanza A, Reifenberger N, Habeck G, Becker J, Calabrese M, Urlaub H, Lorenz H, Schulman B, Scita G, Melchior F
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(2013) Sub-angstromresolution crystallography reveals physical distortions that enhance reactivity of a covalent enzymatic intermediate. Nat Chem (9):762-767
Luedtke S, Neumann P, Erixon K, Leeper F, Kluger R, Ficner R, Tittmann K
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(2013) Targeted decay of a regulatory small RNA by an adaptor protein for RNase E and counteraction by an anti-adaptor RNA. Genes Dev (5):552-564
Goepel Y, Papenfort K, Reichenbach B, Vogel J, Goerke B
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(2014) Cell biology. Powering the cell cycle. Science 346(6213):1059-1060
Schulz C, Rehling P
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(2014) Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins. Science 344(6187):1023-1028
Wilhelm B, Mandad S, Truckenbrodt S, Kroehnert K, Schaefer C, Rammner B, Koo S, Classen G, Krauss M, Haucke V, Urlaub H, Rizzoli S
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(2014) Dlk1 Promotes a Fast Motor Neuron Biophysical Signature Required for Peak Force Execution. Science 343(6176):1264-1266
Mueller D, Cherukuri P, Henningfeld K, Poh C, Wittler L, Grote P, Schlueter O, Schmidt J, Laborda J, Bauer S, Brownstone R, Marquardt T
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(2014) Ion permeation in K+ channels occurs by direct Coulomb knock-on. Science 346(6207):352-355
Köpfer D, Song C, Gruene T, Sheldrick G, Zachariae U, de Groot B
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(2014) Myelin Membrane Wrapping of CNS Axons by PI(3,4,5) P3- Dependent Polarized Growth at the Inner Tongue. Cell 156(1-2):277-290
Snaidero N, Moebius W, Czopka T, Hekking L, Mathisen C, Verkleij D, Goebbels S, Edgar J, Merkler D, Lyons D, Nave K, Simons M
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(2014) Photo-cross-linking and high-resolution mass spectrometry for assignment of RNA-binding sites in RNA-binding proteins. Nat Methods 11(10):1064-1070
Kramer K, Sachsenberg T, Beckmann B, Qamar S, Boon K, Hentze M, Kohlbacher O, Urlaub H
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(2014) Programmed -1 frameshifting by kinetic partitioning during impeded translocation. Cell 157(7):1619-1631
Caliskan N, Katunin V, Belardinelli R, Peske F, Rodnina M
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(2014) Site-Specific Labeling of RNA at Internal Ribose Hydroxyl Groups: Terbium-Assisted Deoxyribozymes at Work. J Am Chem Soc 136(22):8131-8137
Buettner L, Javadi-Zarnaghi F, Hoebartner C
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(2014) The Protein Targeting Factor Get3 Functions as ATP-Independent Chaperone under Oxidative Stress Conditions. Mol Cell 56(1):116-127
Voth W, Schick M, Gates S, Li S, Vilardi F, Gostimskaya I, Southworth D, Schwappach B, Jakob U
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(2014) Uniquantal Release through a Dynamic Fusion Pore Is a Candidate Mechanism of Hair Cell Exocytosis. Neuron 83(6):1389-1403
Chapochnikov N, Takago H, Huang C, Pangrsic T, Khimich D, Neef J, Auge E, Göttfert F, Hell S, Wichmann C, Wolf F, Moser T
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(2014) Vesicular Glutamate Transporters Use Flexible Anion and Cation Binding Sites for Efficient Accumulation of Neurotransmitter. Neuron 84(6):1287-1301
Preobraschenski J, Zander J, Suzuki T, Ahnert-Hilger G, Jahn R
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(2015) Brain Energy Metabolism: Conserved Functions of Glycolytic Glial Cells. Cell Metab 22(3):361-363
Trevisiol A, Nave K
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(2015) Cell type- and brain region-resolved mouse brain proteome. Nat Neurosci 18(12):1819-1831
Sharma K, Schmitt S, Bergner C, Tyanova S, Kannaiyan N, Manrique-Hoyos N, Kongi K, Cantuti L, Hanisch U, Philips M, Rossner M, Mann M, Simons M
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(2015) Crystal structure of the metazoan Nup62.Nup58.Nup54 nucleoporin complex. Science 350(6256):106-110
Chug H, Trakhanov S, Huelsmann B, Pleiner T, Goerlich D
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(2015) Mic10 Oligomerizes to Bend Mitochondrial Inner Membranes at Cristae Junctions. Cell Metab 21(5):756-763
Barbot M, Jans D, Schulz C, Denkert N, Kroppen B, Hoppert M, Jakobs S, Meinecke M
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(2015) Multiple Paramagnetic Effects through a Tagged Reporter Protein. Angew Chem, Int Ed 54(1):336-339
Camacho Zarco A, Munari F, Wegstroth M, Liu W, Ubbink M, Becker S, Zweckstetter M
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(2015) Sampling of Glycan-Bound Conformers by the Anti-HIV Lectin Oscillatoria agardhii agglutinin in the Absence of Sugar. Angew Chem, Int Ed 54(22):6462-6465
Carneiro M, Koharudin L, Ban D, Sabo T, Trigo-Mourino P, Mazur A, Griesinger C, Gronenborn A, Lee D
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(2015) Secondary-Ion Mass Spectrometry of Genetically Encoded Targets. Angew Chem, Int Ed 54(19):5784-5788
Vreja I, Kabatas S, Saka S, Krohnert K, Hoeschen C, Opazo F, Diederichsen U, Rizzoli S
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(2015) Sip1 Downstream Effector ninein Controls Neocortical Axonal Growth, Ipsilateral Branching, and Microtubule Growth and Stability. Neuron 85(5):998-1012
Srivatsa S, Parthasarathy S, Molnar Z, Tarabykin V
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(2015) Superresolution Microscopy of Clickable Amino Acids Reveals the Effects of Fluorescent Protein Tagging on Protein Assemblies. ACS Nano 9(11):11034-11041
Vreja I, Nikic I, Göttfert F, Bates M, Kröhnert K, Outeiro T, Hell S, Lemke E, Rizzoli S
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2015) MicroRNA-101 Suppresses Tumor Cell Proliferation by Acting as an Endogenous Proteasome Inhibitor via Targeting the Proteasome Assembly Factor POMP. Mol Cell 59(2):243-257
Zhang X, Schulz R, Edmunds S, Krüger E, Markert E, Gaedcke J, Cormet-Boyaka E, Ghadimi M, Beissbarth T, Levine A, Moll U, Dobbelstein M
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(2016) Broken detailed balance at mesoscopic scales in active biological systems. Science 352(6285):604-607
Battle C, Broedersz C, Fakhri N, Geyer V, Howard J, Schmidt C, MacKintosh F
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(2016) Cilia-based flow network in the brain ventricles. Science 353(6295):176-178
Faubel R, Westendorf C, Bodenschatz E, Eichele G
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(2016) Crystal structure of a DNA catalyst. Nature 529(7585):231-U272
Ponce-Salvatierra A, Wawrzyniak-Turek K, Steuerwald U, Höbartner C, Pena V
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(2016) Engineered non-Mendelian inheritance of entire parental genomes in C. elegans. Nat Biotechnol 34(9):982
Besseling J, Bringmann H
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(2016) MDM2 Associates with Polycomb Repressor Complex 2 and Enhances Stemness-Promoting Chromatin Modifications Independent of p53. Mol Cell 61(1):68-83
Wienken M, Dickmanns A, Nemajerova A, Kramer D, Najafova Z, Weiss M, Karpiuk O, Kassem M, Zhang Y, Lozano G, Johnsen S, Moll U, Zhang X, Dobbelstein M
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(2016) Molecular Architecture of SF3b and Structural Consequences of Its Cancer-Related Mutations. Mol Cell 64(2):307-319
Cretu C, Schmitzová J, Ponce-Salvatierra A, Dybkov O, De Laurentiis, Sharma K, Will C, Urlaub H, Lührmann R, Pena V
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(2016) mRNA quality control is bypassed for immediate export of stress-responsive transcripts. Nature 540(7634):593-596
Zander G, Hackmann A, Bender L, Becker D, Lingner T, Salinas G, Krebber H
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(2016) Single-vesicle imaging reveals different transport mechanisms between glutamatergic and GABAergic vesicles. Science 351(6276):981-984
Farsi Z, Preobraschenski J, van den Bogaart G, Riedel D, Jahn R, Woehler A
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(2016) The Low Barrier Hydrogen Bond in the Photoactive Yellow Protein: A Vacuum Artifact Absent in the Crystal and Solution. J Am Chem Soc 138(51):16620-16631
Graen T, Inhester L, Clemens M, Grubmüller H, Groenhof G
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(2016) X-rays Reveal the Internal Structure of Keratin Bundles in Whole Cells. ACS Nano 10(3):3553-3561
Hémonnot C, Reinhardt J, Saldanha O, Patommel J, Graceffa R, Weinhausen B, Burghammer M, Schroer C, Köster S
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(2017) Adrenergic Gate Release for Spike Timing-Dependent Synaptic Potentiation. Neuron 93(2):394-408
Liu YL, Cui L, Schwarz MK, Dong Y, Schlüter OM
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(2017) Backbone assignment of perdeuterated proteins by solid-state NMR using proton detection and ultrafast magic-angle spinning. Nat Protoc 12(4):764-782
Fricke P, Chevelkov V, Zinke M, Giller K, Becker S, Lange A
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(2017) Conditional Switch between Frameshifting Regimes upon Translation of dnaX mRNA. Mol Cell 66(4):558-567
Caliskan N, Wohlgemuth I, Korniy N, Pearson M, Peske F, Rodnina MV
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(2017) Cryo-EM structure of a human spliceosome activated for step 2 of splicing. Nature 542(7641):318-323
Bertram K, Agafonov D, Liu W, Dybkov O, Will C, Hartmuth K, Urlaub H, Kastner B, Stark H, Luehrmann R
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(2017) Cryo-EM Structure of a Pre-catalytic Human Spliceosome Primed for Activation. Cell 170(4):701-713
Bertram K, Agafonov DE, Dybkov O, Haselbach D, Leelaram MN, Will CL, Urlaub H, Kastner B, Lührmann R, Stark H
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(2017) Dietary cholesterol promotes repair of demyelinated lesions in the adult brain. Nat Commun 8:14241
Berghoff SA, Gerndt N, Winchenbach J, Stumpf SK, Hosang L, Odoardi F, Ruhwedel T, Bohler C, Barrette B, Stassart R, Liebetanz D, Dibaj P, Möbius W, Edgar JM, Saher G
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(2017) Flexible information routing by transient synchrony. Nat Neurosci 20(7):1014
Palmigiano A, Geisel T, Wolf F, Battaglia D
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(2017) Imaging of Biological Materials and Cells by X-ray Scattering and Diffraction. ACS Nano 11(9):8542-8559
Hemonnot CYJ, Köster S
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(2017) INA complex liaises the F1Fo-ATP synthase membrane motor modules. Nat Commun 8:1237
Naumenko N, Morgenstern M, Rucktaschel R, Warscheid B, Rehling P
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(2017) Kinetic Requirements for Spatiotemporal Chemical Imaging with Fluorescent Nanosensors. ACS Nano 11(4):4017-4027
Meyer D, Hagemann A, Kruss S
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(2017) Long-range allosteric regulation of the human 26S proteasome by 20S proteasome-targeting cancer drugs. Nat Commun 8:15578
Haselbach D, Schrader J, Lambrecht F, Henneberg F, Chari A, Stark H
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(2017) Model-free inference of direct network interactions from nonlinear collective dynamics. Nat Commun 8:2192
Casadiego J, Nitzan M, Hallerberg S, Timme M
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(2017) One-thousand-fold enhancement of high field liquid nuclear magnetic resonance signals at room temperature. Nat Chem 9(7):676-680
Liu GQ, Levien M, Karschin N, Parigi G, Luchinat C, Bennati M
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(2017) RNF40 regulates gene expression in an epigenetic context-dependent manner. Genome Biol 18:32
Xie WH, Nagarajan S, Baumgart SJ, Kosinsky RL, Najafova Z, Kari V, Hennion M, Indenbirken D, Bonn S, Grundhoff A, Wegwitz F, Mansouri A, Johnsen SA
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(2017) Structures of transcription pre-initiation complex with TFIIH and Mediator. Nature 551(7679):204-209
Schilbach S, Hantsche M, Tegunov D, Dienemann C, Wigge C, Urlaub H, Cramer P
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(2018) Adhesion of Chlamydomonas microalgae to surfaces is switchable by light. Nat Phys 14(1):45-49
Kreis CT, Le Blay M, Linne C, Makowski MM, Bäumchen O
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(2018) Chromatin swelling drives neutrophil extracellular trap release. Nat Commun 9:3767
Neubert E, Meyer D, Rocca F, Gunay G, Kwaczala-Tessmann A, Grandke J, Senger-Sander S, Geisler C, Egner A, Schön MP, Erpenbeck L, Kruss S
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(2018) Correlative microscopy approach for biology using X-ray holography, X-ray scanning diffraction and STED microscopy. Nat Commun 9:3641
Bernhardt M, Nicolas JD, Osterhoff M, Mittelstädt H, Reuss M, Harke B, Wittmeier A, Sprung M, Köster S, Salditt T
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(2018) Electromechanical vortex filaments during cardiac fibrillation. Nature 555(7698):667
Christoph J, Chebbok M, Richter C, Schröder-Schetelig J, Bittihn P, Stein S, Uzelac I, Fenton FH, Hasenfuss G, Gilmour RF, Luther S
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(2018) IgSF9b regulates anxiety behaviors through effects on centromedial amygdala inhibitory synapses. Nat Commun 9:5400
Babaev O, Cruces-Solis H, Chatain CP, Hammer M, Wenger S, Ali H, Karalis N, de Hoz L, Schlüter OM, Yanagawa Y, Ehrenreich H, Taschenberger H, Brose N, Krueger-Burg D
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(2018) Motor recruitment to the TIM23 channel's lateral gate restricts polypeptide release into the inner membrane. Nat Commun 9:4028
Schendzielorz AB, Bragoszewski P, Naumenko N, Gomkale R, Schulz C, Guiard B, Chacinska A, Rehling P
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(2018) PNA Hybrid Sequences as Recognition Units in SNARE-Protein-Mimicking Peptides. Angew Chem, Int Ed 57(45):14932-14936
Hubrich BE, Kumar P, Neitz H, Grunwald M, Grothe T, Walla PJ, Jahn R, Diederichsen U
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(2018) Quantitative optical nanophysiology of Ca2+ signaling at inner hair cell active zones. Nat Commun 9:290
Neef J, Urban NT, Ohn TL, Frank T, Jean P, Hell SW, Willig KI, Moser T
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(2018) RNA helicases mediate structural transitions and compositional changes in pre-ribosomal complexes. Nat Commun 9:5383
Brüning L, Hackert P, Martin R, Gallesio JD, Aquino GRR, Urlaub H, Sloan KE, Bohnsack MT
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(2018) RNA polymerase II clustering through carboxy-terminal domain phase separation. Nat Struct Mol Biol 25(9):833-840
Boehning M, Dugast-Darzacq C, Rankovic M, Hansen AS, Yu T, Marie-Nelly H, McSwiggen DT, Kokic G, Dailey GM, Cramer P, Darzacq X, Zweckstetter M
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(2018) Structure and Conformational Dynamics of the Human Spliceosomal B- act Complex. Cell 172(3):454-464
Haselbach D, Komarov I, Agafonov DE, Hartmuth K, Graf B, Dybkov O, Urlaub H, Kastner B, Luhrmann R, Stark H
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(2018) Structure determination from single molecule X- ray scattering with three photons per image. Nat Commun 9:2375
von Ardenne B, Mechelke M, Grubmüller H
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(2018) Surface Properties Determining Passage Rates of Proteins through Nuclear Pores. Cell 174(1):202-217
Frey S, Rees R, Schünemann J, Ng SC, Fünfgeld K, Huyton T, Görlich D
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(2019) Activity Correlations between Direction-Selective Retinal Ganglion Cells Synergistically Enhance Motion Decoding from Complex Visual Scenes. Neuron 101(5):963-976.e7
Kuhn NK, Gollisch T
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(2019) Boron-Containing Probes for Non-optical High-Resolution Imaging of Biological Samples. ANGEW CHEM, INT ED 58(11):3438-3443
Kabatas S, Agui-Gonzalez P, Saal KA, Jähne S, Opazo F, Rizzoli SO, Phan NTN
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(2019) Near physiological spectral selectivity of cochlear optogenetics. Nat Commun 10:1962
Dieter A, Duque-Afonso CJ, Rankovic V, Jeschke M, Moser T
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(2019) NRG1 type I dependent autoparacrine stimulation of Schwann cells in onion bulbs of peripheral neuropathies. Nat Commun 10:1467
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