GSC 249: Die Hartmut Hoffmann-Berling Internationale Graduiertenschule für Molekular- und Zellbiologie Heidelberg
Zusammenfassung der Projektergebnisse
Die Hartmut Hoffmann-Berling International Graduate School of Molecular & Cellular Biology Heidelberg, im Jahr 2018 umbenannt in Heidelberg Biosciences International Graduate School - nachfolgend „HBIGS“ -, wurde im Oktober 2007 mit dem Ziel gegründet, die motiviertesten und talentiertesten Doktoranden aus aller Welt für eine anspruchsvolle Promotion an der Universität Heidelberg zu gewinnen. Die HBIGS hat sich seitdem zum größten strukturierten Graduiertenprogramm für Lebenswissenschaften an der Universität Heidelberg entwickelt. In der ersten Förderphase hat die HBIGS aus ihrer Sicht wichtige neue Maßnahmen in der Doktorandenausbildung eingeführt, wozu u.a. die Stärkung interdisziplinärer Forschungsansätze, ein strukturiertes Doktorandenprogramm, die Einrichtung individueller Betreuungskomittes („Thesis Advisory Committees“) für Doktoranden, die Einführung eines Berufsvorbereitungskonzepts, die Integration und Weiterentwicklung eines MD/PhD Programms sowie die Förderung von Frauen und Wissenschaftlern mit Familie gehörten. In der zweiten Förderperiode wurde HBIGS von einer thematisch fokussierten Graduiertenschule in eine Graduiertenschule der molekularen Lebenswissenschaften weiterentwickelt, welche die Gesamtheit der lebenswissenschaftlichen Fächer der Universität Heidelberg sowie außeruniversitärer Einrichtungen umfasst. Unter dem Dach der HBIGS wurden im Berichtszeitraum mehr als ein Dutzend nationale und internationale Graduiertenprogramme initiiert und verwaltet. Mit über 80% internationalen Bewerbern respektive 40% internationalen Doktoranden machen die HBIGS zu einer echten internationalen Graduiertenschule, deren akademische Exzellenz durch über 1500 referierte Veröffentlichungen in wissenschaftlichen Fachzeitschriften, eine durchschnittliche Promotionszeit von 4,1 Jahren, eine niedrige Schwundquote von 8%, eine ausgewogene Geschlechterverteilung und ausgezeichnete berufliche Perspektiven für die Promovenden bezeugt wird.
Projektbezogene Publikationen (Auswahl)
-
(2010). Components of the Hippo pathway cooperate with Nek2 kinase to regulate centrosome disjunction. Nat Cell Biol
Mardin, Balca R.; Lange, Cornelia; Baxter, Joanne E.; Hardy, Tara; Scholz, Sebastian R.; Fry, Andrew M. & Schiebel, Elmar
-
(2010). Mutations detected in the SHANK2 synaptic scaffolding gene in autism spectrum disorder and mental retardation. Nat Genet
Berkel, Simone; Marshall, Christian R.; Weiss, Birgit; Howe, Jennifer; Roeth, Ralph; Moog, Ute; Endris, Volker; Roberts, Wendy; Szatmari, Peter; Pinto, Dalila; Bonin, Michael; Riess, Angelika; Engels, Hartmut; Sprengel, Rolf; Scherer, Stephen W. & Rappold
-
(2010). Stimulation of Cell Adhesion at nanostructured Teflon Interfaces. Advanced Materials
Kruss, Sebastian; Wolfram, Tobias; Martin, Raquel; Neubauer, Stefanie; Kessler, Horst & Spatz, Joachim P.
-
(2011). Hepatic deficiency in transcriptional cofactor TBL1 promotes liver steatosis and hypertriglyceridemia. Cell Metab
Kulozik, Philipp; Jones, Allan; Mattijssen, Frits; Rose, Adam J.; Reimann, Anja; Strzoda, Daniela; Kleinsorg, Stefan; Raupp, Christina; Kleinschmidt, Jürgen; Müller-Decker, Karin; Wahli, Walter; Sticht, Carsten; Gretz, Norbert; von Loeffelholz, Christian; Stockmann, Martin; Pfeiffer, Andreas; Stöhr, Sigrid; Dallinga-Thie, Geesje M.; Nawroth, Peter P.; ... & Herzig, Stephan
-
(2011). Mapping of Signalling Networks through Synthetic Genetic Interaction Analysis by RNAi. Nature Methods
Horn, Thomas; Sandmann, Thomas; Fischer, Bernd; Axelsson, Elin; Huber, Wolfgang & Boutros, Michael
-
(2011). Recruitment and Activation of a Lipid Kinase by Hepatitis C Virus NS5A Is Essential for Integrity of the Membranous Replication Compartment. Cell Host Microbe
Reiss, Simon; Rebhan, Ilka; Backes, Perdita; Romero-Brey, Ines; Erfle, Holger; Matula, Petr; Kaderali, Lars; Poenisch, Marion; Blankenburg, Hagen; Hiet, Marie-Sophie; Longerich, Thomas; Diehl, Sarah; Ramirez, Fidel; Balla, Tamas; Rohr, Karl; Kaul, Artur; Bühler, Sandra; Pepperkok, Rainer; Lengauer, Thomas; ... & Bartenschlager, Ralf
-
(2012). An extended gamma-tubulin ring functions as a stable platform in microtubule nucleation. J Cell Biol
Erlemann, Sarah; Neuner, Annett; Gombos, Linda; Gibeaux, Romain; Antony, Claude & Schiebel, Elmar
-
(2012). Identification of type I and type II interferon-induced effectors controlling hepatitis C virus replication. Hepatology
Metz, Philippe; Dazert, Eva; Ruggieri, Alessia; Mazur, Johanna; Kaderali, Lars; Kaul, Artur; Zeuge, Ulf; Windisch, Marc P.; Trippler, Martin; Lohmann, Volker; Binder, Marco; Frese, Michael & Bartenschlager, Ralf
-
(2012). Rif2 Promotes a Telomere Fold-Back Structure through Rpd3L Recruitment in Budding Yeast. PLoS Genet
Poschke, Heiko; Dees, Martina; Chang, Michael; Amberkar, Sandeep; Kaderali, Lars; Rothstein, Rodney & Luke, Brian
-
(2012). Site-specific terminal and internal labeling of RNA by poly(A) polymerase tailing and copper-catalyzed or copper-free strainpromoted click chemistry. Nucleic Acids Res
Winz, Marie-Luise; Samanta, Ayan; Benzinger, Dirk & Jäschke, Andres
-
(2012). Structure and Dynamics of the ATP-Bound Open Conformation of Hsp70 Chaperones. Mol Cell
Kityk, Roman; Kopp, Jürgen; Sinning, Irmgard & Mayer, Matthias P.
-
(2012). Ubiquitin-Dependent Intramembrane Rhomboid Protease Promotes ERAD of Membrane Proteins. Mol Cell
Fleig, Lina; Bergbold, Nina; Sahasrabudhe, Priyanka; Geiger, Beate; Kaltak, Lejla & Lemberg, Marius K.
-
(2013). Analysis of hepatitis C virus resistance to silibinin in vitro and in vivo points to a novel mechanism involving nonstructural protein 4B. Hepatology
Esser-Nobis, Katharina; Romero-Brey, Inés; Ganten, Tom M.; Gouttenoire, Jérôme; Harak, Christian; Klein, Rahel; Schemmer, Peter; Binder, Marco; Schnitzler, Paul; Moradpour, Darius; Bartenschlager, Ralf; Polyak, Stephen J.; Stremmel, Wolfgang; Penin, François; Eisenbach, Christoph & Lohmann, Volker
-
(2013). Detecting endogenous SUMO targets in mammalian cells and tissues. Nat Struct Mol Biol
Becker, Janina; Barysch, Sina V; Karaca, Samir; Dittner, Claudia; Hsiao, He-Hsuan; Diaz, Mauricio Berriel; Herzig, Stephan; Urlaub, Henning & Melchior, Frauke
-
(2013). Posttranscriptional regulation of the trypanosome heat shock response by a zinc finger protein. PLoS Pathog
Droll, Dorothea; Minia, Igor; Fadda, Abeer; Singh, Aditi; Stewart, Mhairi; Queiroz, Rafael & Clayton, Christine
-
(2013). Telomeric RNA-DNA hybrids affect telomere-length dynamics and senescence. Nat Struct Mol Biol
Balk, Bettina; Maicher, André; Dees, Martina; Klermund, Julia; Luke-Glaser, Sarah; Bender, Katharina & Luke, Brian
-
(2013). The Lipid Kinase Phosphatidylinositol-4 Kinase III Alpha Regulates the Phosphorylation Status of Hepatitis C Virus NS5A. PLoS Pathog
Reiss, Simon; Harak, Christian; Romero-Brey, Inés; Radujkovic, Danijela; Klein, Rahel; Ruggieri, Alessia; Rebhan, Ilka; Bartenschlager, Ralf & Lohmann, Volker
-
(2013). Tunable Substrates Unveil Chemical Complementation of a Genetic Cell Migration Defect. Adv Healthc Mater
Hellmann, Janina Kristin; Perschmann, Nadine; Spatz, Joachim P. & Frischknecht, Friedrich
-
2014). Highly efficient CRISPR/Cas9-mediated knock-in in zebrafish by homology-independent DNA repair. Genome Res
Auer, Thomas O.; Duroure, Karine; De Cian, Anne; Concordet, Jean-Paul & Del Bene, Filippo
-
(2014). A mechanistic framework for noncell autonomous stem cell induction in Arabidopsis. Proc Natl Acad Sci USA
Daum, Gabor; Medzihradszky, Anna; Suzaki, Takuya & Lohmann, Jan U.
-
(2014). A TOGL domain specifically targets yeast CLASP to kinetochores to stabilize kinetochore microtubules. J Cell Biol
Funk, Caroline; Schmeiser, Verena; Ortiz, Jennifer & Lechner, Johannes
-
(2014). A vaccine targeting mutant IDH1 induces antitumour immunity. Nature
Schumacher, Theresa; Bunse, Lukas; Pusch, Stefan; Sahm, Felix; Wiestler, Benedikt; Quandt, Jasmin; Menn, Oliver; Osswald, Matthias; Oezen, Iris; Ott, Martina; Keil, Melanie; Balß, Jörg; Rauschenbach, Katharina; Grabowska, Agnieszka K.; Vogler, Isabel; Diekmann, Jan; Trautwein, Nico; Eichmüller, Stefan B.; Okun, Jürgen; ... & Platten, Michael
-
(2014). Cyclosporin A inhibits Hepatitis B and Hepatitis D Virus entry by Cyclophilin-independent interference with the NTCP receptor. J Hepatol
Nkongolo, Shirin; Ni, Yi; Lempp, Florian A.; Kaufman, Christina; Lindner, Thomas; Esser-Nobis, Katharina; Lohmann, Volker; Mier, Walter; Mehrle, Stefan & Urban, Stephan
-
(2014). Cytosolic peroxidases protect the lysosome of bloodstream african trypanosomes from ironmediated membrane damage. PLoS Pathog
Hiller, Corinna; Nissen, Amrei; Benítez, Diego; Comini, Marcelo A. & Krauth-Siegel, R. Luise
-
(2014). E-CRISP: fast CRISPR target site identification. Nat Methods
Heigwer, Florian; Kerr, Grainne & Boutros, Michael
-
(2014). Elements in nucleotide sensing and hydrolysis of the AAA+ disaggregation machine ClpB: a structurebased mechanistic dissection of a molecular motor. Acta Crystallogr D Biol Crystallogr
Zeymer, Cathleen; Barends, Thomas R. M.; Werbeck, Nicolas D.; Schlichting, Ilme & Reinstein, Jochen
-
(2014). Male-female communication triggers calcium signatures during fertilization in Arabidopsis. Nat Commun
Denninger, Philipp; Bleckmann, Andrea; Lausser, Andreas; Vogler, Frank; Ott, Thomas; Ehrhardt, David W.; Frommer, Wolf B.; Sprunck, Stefanie; Dresselhaus, Thomas & Grossmann, Guido
-
(2014). RGS5 promotes arterial growth during arteriogenesis. EMBO Mol Med
Arnold, Caroline; Feldner, Anja; Pfisterer, Larissa; Hödebeck, Maren; Troidl, Kerstin; Genové, Guillem; Wieland, Thomas; Hecker, Markus & Korff, Thomas
-
(2014). RNA Specificity and Regulation of Catalysis in the Eukaryotic Polynucleotide Kinase Clp1. Mol Cell
Dikfidan, Aytac; Loll, Bernhard; Zeymer, Cathleen; Magler, Iris; Clausen, Tim & Meinhart, Anton
-
(2014). Signal peptide peptidase functions in ERAD to cleave the unfolded protein response regulator XBP1u. EMBO J
Chen, Chia‐Yi; Malchus, Nicole S.; Hehn, Beate; Stelzer, Walter; Avci, Dönem; Langosch, Dieter & Lemberg, Marius K.
-
(2014). Structure of the complete bacterial SRP Alu domain. Nucleic Acids Res
Kempf, Georg; Wild, Klemens & Sinning, Irmgard
-
(2014). The E3 Ligase CUL3/RDX Controls Centromere Maintenance by Ubiquitylating and Stabilizing CENP-A in a CAL1-Dependent Manner. Dev Cell
Bade, Debora; Pauleau, Anne-Laure; Wendler, Astrid & Erhardt, Sylvia
-
(2014). The Yeast ER- Intramembrane Protease Ypf1 Refines Nutrient Sensing by Regulating Transporter Abundance. Mol Cell
Avci, Dönem; Fuchs, Shai; Schrul, Bianca; Fukumori, Akio; Breker, Michal; Frumkin, Idan; Chen, Chia-yi; Biniossek, Martin L.; Kremmer, Elisabeth; Schilling, Oliver; Steiner, Harald; Schuldiner, Maya & Lemberg, Marius K.
-
(2014). Translational Regulation of Specific mRNAs Controls Feedback Inhibition and Survival during Macrophage Activation. PLoS Genet
Schott, Johanna; Reitter, Sonja; Philipp, Janine; Haneke, Katharina; Schäfer, Heiner & Stoecklin, Georg
-
2014). Quantitative determination of decitabine incorporation into DNA and its effect on mutation rates in human cancer cells. Nucleic Acids Res
Öz, Simin; Raddatz, Günter; Rius, Maria; Blagitko-Dorfs, Nadja; Lübbert, Michael; Maercker, Christian & Lyko, Frank
-
(2012). The cisregulatory code of Hox function in Drosophila. EMBO J
Sorge, Sebastian; Ha, Nati; Polychronidou, Maria; Friedrich, Jana; Bezdan, Daniela; Kaspar, Petra; Schaefer, Martin H; Ossowski, Stephan; Henz, Stefan R; Mundorf, Juliane; Rätzer, Jenny; Papagiannouli, Fani & Lohmann, Ingrid
-
(2015). A Functional Role for VEGFR1 Expressed in Peripheral Sensory Neurons in Cancer Pain. Cancer Cell
Selvaraj, Deepitha; Gangadharan, Vijayan; Michalski, Christoph W.; Kurejova, Martina; Stösser, Sebastian; Srivastava, Kshitij; Schweizerhof, Matthias; Waltenberger, Johannes; Ferrara, Napoleone; Heppenstall, Paul; Shibuya, Masabumi; Augustin, Hellmut G. & Kuner, Rohini
-
(2015). Alleviation of off-target effects from vector-encoded shRNAs via codelivered RNA decoys. Proc Natl Acad Sci USA,
Mockenhaupt, Stefan; Grosse, Stefanie; Rupp, Daniel; Bartenschlager, Ralf & Grimm, Dirk
-
(2015). Downregulation of N-terminal acetylation triggers ABA-mediated drought responses in Arabidopsis. Nat Commun
Linster, Eric; Stephan, Iwona; Bienvenut, Willy V.; Maple-Grødem, Jodi; Myklebust, Line M.; Huber, Monika; Reichelt, Michael; Sticht, Carsten; Geir Møller, Simon; Meinnel, Thierry; Arnesen, Thomas; Giglione, Carmela; Hell, Rüdiger & Wirtz, Markus
-
(2015). Identification and functional characterization of rare SHANK2 variants in schizophrenia. Mol Psychiatry
Peykov, S.; Berkel, S.; Schoen, M.; Weiss, K.; Degenhardt, F.; Strohmaier, J.; Weiss, B.; Proepper, C.; Schratt, G.; Nöthen, M. M.; Boeckers, T. M.; Rietschel, M. & Rappold, G. A.
-
(2015). Intramembrane protease PARL defines a negative regulator of PINK1- and PARK2/Parkin-dependent mitophagy. Autophagy
Meissner, Cathrin; Lorenz, Holger; Hehn, Beate & Lemberg, Marius K.
-
(2015). Nanoscale control of surface immobilized BMP-2: toward a quantitative assessment of BMP-mediated signaling events. Nano Lett
Schwab, Elisabeth H.; Pohl, Theresa L. M.; Haraszti, Tamás; Schwaerzer, Gerburg K.; Hiepen, Christian; Spatz, Joachim P.; Knaus, Petra & Cavalcanti-Adam, Elisabetta A.
-
(2015). Operon structure and cotranslational subunit association direct protein assembly in bacteria. Science
Shieh, Yu-Wei; Minguez, Pablo; Bork, Peer; Auburger, Josef J.; Guilbride, D. Lys; Kramer, Günter & Bukau, Bernd
-
(2015). Regional Cell-Specific Transcriptome Mapping Reveals Regulatory Complexity in the Adult Drosophila Midgut. Cell Rep
Dutta, Devanjali; Dobson, Adam J.; Houtz, Philip L.; Gläßer, Christine; Revah, Jonathan; Korzelius, Jerome; Patel, Parthive H.; Edgar, Bruce A. & Buchon, Nicolas
-
(2015). Somatic CRISPR/Cas9-mediated tumour suppressor disruption enables versatile brain tumour modelling. Nat Commun
Zuckermann, Marc; Hovestadt, Volker; Knobbe-Thomsen, Christiane B.; Zapatka, Marc; Northcott, Paul A.; Schramm, Kathrin; Belic, Jelena; Jones, David T. W.; Tschida, Barbara; Moriarity, Branden; Largaespada, David; Roussel, Martine F.; Korshunov, Andrey; Reifenberger, Guido; Pfister, Stefan M.; Lichter, Peter; Kawauchi, Daisuke & Gronych, Jan
-
(2015). Sox2, Tlx, Gli3 and Her9 converge on Rx2 to define retinal stem cells in vivo. EMBO J
Reinhardt, Robert; Centanin, Lázaro; Tavhelidse, Tinatini; Inoue, Daigo; Wittbrodt, Beate; Concordet, Jean‐Paul; Martinez‐Morales, Juan Ramón & Wittbrodt, Joachim
-
(2015). Structural basis for assembly and function of the Nup82 complex in the nuclear pore scaffold. J Cell Biol
Gaik, Monika; Flemming, Dirk; von Appen, Alexander; Kastritis, Panagiotis; Mücke, Norbert; Fischer, Jessica; Stelter, Philipp; Ori, Alessandro; Bui, Khanh Huy; Baßler, Jochen; Barbar, Elisar; Beck, Martin & Hurt, Ed
-
(2015). The inner workings of the hydrazine synthase multiprotein complex. Nature
Dietl, Andreas; Ferousi, Christina; Maalcke, Wouter J.; Menzel, Andreas; de Vries, Simon; Keltjens, Jan T.; Jetten, Mike S. M.; Kartal, Boran & Barends, Thomas R. M.
-
(2015). The serine protease inhibitor Serpin A3N attenuates neuropathic pain by inhibiting T cell-derived leukocyte elastase. Nat Med
Vicuña, Lucas; Strochlic, David E; Latremoliere, Alban; Bali, Kiran Kumar; Simonetti, Manuela; Husainie, Dewi; Prokosch, Sandra; Riva, Priscilla; Griffin, Robert S; Njoo, Christian; Gehrig, Stefanie; Mall, Marcus A; Arnold, Bernd; Devor, Marshall; Woolf, Clifford J; Liberles, Stephen D; Costigan, Michael & Kuner, Rohini
-
(2015). Transcriptional refractoriness is dependent on core promoter architecture. Nat Commun
Cesbron, François; Oehler, Michael; Ha, Nati; Sancar, Gencer & Brunner, Michael
-
(2015). X-domain of peptide synthetases recruits oxygenases crucial for glycopeptide biosynthesis. Nature
Haslinger, Kristina; Peschke, Madeleine; Brieke, Clara; Maximowitsch, Egle & Cryle, Max J.
-
2015). A Time-Calibrated Road Map of Brassicaceae Species Radiation and Evolutionary History. Plant Cell
Hohmann, Nora; Wolf, Eva M.; Lysak, Martin A. & Koch, Marcus A.
-
Compartment-specific aggregases direct distinct nuclear and cytoplasmic aggregate deposition. EMBO J
Miller, Stephanie BM; Ho, Chi‐Ting; Winkler, Juliane; Khokhrina, Maria; Neuner, Annett; Mohamed, Mohamed YH; Guilbride, D Lys; Richter, Karsten; Lisby, Michael; Schiebel, Elmar; Mogk, Axel & Bukau, Bernd
-
(2015). Evidence that hepatitis B virus replication in mouse cells is limited by the lack of a host cell dependency factor. J Hepatol
Lempp, Florian A.; Mutz, Pascal; Lipps, Christoph; Wirth, Dagmar; Bartenschlager, Ralf & Urban, Stephan
-
(2016). A FRET-based study reveals site-specific regulation of spindle position checkpoint proteins at yeast centrosomes. Elife
Gryaznova, Yuliya; Caydasi, Ayse Koca; Malengo, Gabriele; Sourjik, Victor & Pereira, Gislene
-
(2016). Acetylation-Dependent Control of Global Poly(A) RNA Degradation by CBP/p300 and HDAC1/2. Mol Cell
Sharma, Sahil; Poetz, Fabian; Bruer, Marius; Ly-Hartig, Thi Bach Nga; Schott, Johanna; Séraphin, Bertrand & Stoecklin, Georg
-
(2016). Alternative splicing affects the subcellular localization of Drosha. Nucleic Acids Res
Link, Steffen; Grund, Stefanie E. & Diederichs, Sven
-
(2016). Architecture of the 90S pre-ribosome: a structural view on the birth of the eukaryotic ribosome. Cell
Kornprobst, Markus; Turk, Martin; Kellner, Nikola; Cheng, Jingdong; Flemming, Dirk; Koš-Braun, Isabelle; Koš, Martin; Thoms, Matthias; Berninghausen, Otto; Beckmann, Roland & Hurt, Ed
-
(2016). Blue light-induced LOV domain dimerization enhances the affinity of Aureochrome 1a for its target DNA sequence. Elife
Heintz, Udo & Schlichting, Ilme
-
(2016). Global profiling of SRP interaction with nascent polypeptides. Nature
Schibich, Daniela; Gloge, Felix; Pöhner, Ina; Björkholm, Patrik; Wade, Rebecca C.; von Heijne, Gunnar; Bukau, Bernd & Kramer, Günter
-
(2016). New Structural Data Reveal the Motion of Carrier Proteins in Nonribosomal Peptide Synthesis. Angew Chem Int Ed Engl
Kittilä, Tiia; Mollo, Aurelio; Charkoudian, Louise K. & Cryle, Max J.
-
(2016). Progress of endocytic CHRN to autophagic degradation is regulated by RAB5-GTPase and T145 phosphorylation of SH3GLB1 at mouse neuromuscular junctions in vivo. Autophagy
Wild, Franziska; Khan, Muzamil Majid; Straka, Tatjana & Rudolf, Rüdiger
-
(2016). Protein Abundance Control by Non-coding Antisense Transcription. Cell Rep
Huber, Florian; Bunina, Daria; Gupta, Ishaan; Khmelinskii, Anton; Meurer, Matthias; Theer, Patrick; Steinmetz, Lars M. & Knop, Michael
-
(2016). Regulation of the P450 oxygenation cascade involved in glycopeptide antibiotic biosynthesis. J Am Chem Soc
Peschke, Madeleine; Haslinger, Kristina; Brieke, Clara; Reinstein, Jochen & Cryle, Max J.
-
(2016). Retinoic acid catabolizing enzyme CYP26C1 is a genetic modifier in SHOX deficiency. EMBO Mol Med
Montalbano, Antonino; Juergensen, Lonny; Roeth, Ralph; Weiss, Birgit; Fukami, Maki; Fricke‐otto, Susanne; Binder, Gerhard; Ogata, Tsutomu; Decker, Eva; Nuernberg, Gudrun; Hassel, David & Rappold, Gudrun A.
-
(2016). Sensory input attenuation allows predictive sexual response in yeast. Nat Commun
Banderas, Alvaro; Koltai, Mihaly; Anders, Alexander & Sourjik, Victor
-
(2016). Stimulated Emission Depletion Nanoscopy Reveals Time-Course of Human Immunodeficiency Virus Proteolytic Maturation. ACS Nano
Hanne, Janina; Göttfert, Fabian; Schimer, Jiří; Anders-Össwein, Maria; Konvalinka, Jan; Engelhardt, Johann; Müller, Barbara; Hell, Stefan W. & Kräusslich, Hans-Georg
-
(2016). Structures of human SRP72 complexes provide insights into SRP RNA remodeling and ribosome interaction. Nucleic Acids Res
Becker, Matthias M. M.; Lapouge, Karine; Segnitz, Bernd; Wild, Klemens & Sinning, Irmgard
-
(2016). Sugar Influx Sensing by the Phosphotransferase System of Escherichia coli. PLoS Biol
Somavanshi, Rahul; Ghosh, Bhaswar & Sourjik, Victor
-
(2016). SuReSim: simulating localization microscopy experiments from ground truth models. Nat Methods
Venkataramani, Varun; Herrmannsdörfer, Frank; Heilemann, Mike & Kuner, Thomas
-
(2016). TALEN/CRISPR-mediated engineering of a promoterless anti-viral RNAi hairpin into an endogenous miRNA locus. Nucleic Acids Res
Senís, Elena; Mockenhaupt, Stefan; Rupp, Daniel; Bauer, Tobias; Paramasivam, Nagarajan; Knapp, Bettina; Gronych, Jan; Grosse, Stefanie; Windisch, Marc P.; Schmidt, Florian; Theis, Fabian J.; Eils, Roland; Lichter, Peter; Schlesner, Matthias; Bartenschlager, Ralf & Grimm, Dirk
-
(2016). The Crystal Structure of RosB: Insights into the Reaction Mechanism of the First Member of a Family of Flavodoxin-like Enzymes. Angew Chem Int Ed Engl
Konjik, Valentino; Brünle, Steffen; Demmer, Ulrike; Vanselow, Amanda; Sandhoff, Roger; Ermler, Ulrich & Mack, Matthias
-
(2016). The RanBP2/RanGAP1*SUMO1/Ubc9 SUMO E3 ligase is a disassembly machine for Crm1- dependent nuclear export complexes. Nat Commun
Ritterhoff, Tobias; Das, Hrishikesh; Hofhaus, Götz; Schröder, Rasmus R.; Flotho, Annette & Melchior, Frauke
-
(2016). Transient RNA-DNA Hybrids Are Required for Efficient Double- Strand Break Repair. Cell
Ohle, Corina; Tesorero, Rafael; Schermann, Géza; Dobrev, Nikolay; Sinning, Irmgard & Fischer, Tamás
-
(2017). Glutaredoxin catalysis requires two distinct glutathione interaction sites. Nat Commun
Begas, Patricia; Liedgens, Linda; Moseler, Anna; Meyer, Andreas J. & Deponte, Marcel
-
(2017). Heteromeric channels formed by TRPC1, TRPC4 and TRPC5 define hippocampal synaptic transmission and working memory. EMBO J
Bröker‐Lai, Jenny; Kollewe, Astrid; Schindeldecker, Barbara; Pohle, Jörg; Nguyen Chi, Vivan; Mathar, Ilka; Guzman, Raul; Schwarz, Yvonne; Lai, Alan; Weißgerber, Petra; Schwegler, Herbert; Dietrich, Alexander; Both, Martin; Sprengel, Rolf; Draguhn, Andreas; Köhr, Georg; Fakler, Bernd; Flockerzi, Veit; Bruns, Dieter; ... & Freichel, Marc
-
(2017). Human phosphatase CDC14A regulates actin organization through dephosphorylation of epithelial protein lost in neoplasm. Proc Natl Acad Sci USA
Chen, Nan-Peng; Uddin, Borhan; Hardt, Robert; Ding, Wen; Panic, Marko; Lucibello, Ilaria; Kammerer, Patricia; Ruppert, Thomas & Schiebel, Elmar
-
(2017). Induction of Chromosome Instability by Activation of Yes Associated Protein and Forkhead box M1 in Liver Cancer. Gastroenterology
Weiler, Sofia M.E.; Pinna, Federico; Wolf, Thomas; Lutz, Teresa; Geldiyev, Aman; Sticht, Carsten; Knaub, Maria; Thomann, Stefan; Bissinger, Michaela; Wan, Shan; Rössler, Stephanie; Becker, Diana; Gretz, Norbert; Lang, Hauke; Bergmann, Frank; Ustiyan, Vladimir; Kalin, Tatiana V.; Singer, Stephan; Lee, Ju-Seog; ... & Breuhahn, Kai
-
(2017). Motor neurons control blood vessel patterning in the developing spinal cord. Nat Commun
Himmels, Patricia; Paredes, Isidora; Adler, Heike; Karakatsani, Andromachi; Luck, Robert; Marti, Hugo H.; Ermakova, Olga; Rempel, Eugen; Stoeckli, Esther T. & Ruiz de Almodóvar, Carmen
-
(2017). Neural stem cells induce the formation of their physical niche during organogenesis. Elife
Seleit, Ali; Krämer, Isabel; Riebesehl, Bea F; Ambrosio, Elizabeth M; Stolper, Julian S; Lischik, Colin Q; Dross, Nicolas & Centanin, Lazaro
-
(2017). Phosphorylation-Dependent Feedback Inhibition of RIG-I by DAPK1 Identified by Kinome-wide siena Screening. Mol Cell
Willemsen, Joschka; Wicht, Oliver; Wolanski, Julia C.; Baur, Nina; Bastian, Sandra; Haas, Darya A.; Matula, Petr; Knapp, Bettina; Meyniel-Schicklin, Laurène; Wang, Chen; Bartenschlager, Ralf; Lohmann, Volker; Rohr, Karl; Erfle, Holger; Kaderali, Lars; Marcotrigiano, Joseph; Pichlmair, Andreas & Binder, Marco
-
(2017). Profiling Ssb-Nascent Chain Interactions Reveals Principles of Hsp70-Assisted Folding. Cell,
Döring, Kristina; Ahmed, Nabeel; Riemer, Trine; Suresh, Harsha Garadi; Vainshtein, Yevhen; Habich, Markus; Riemer, Jan; Mayer, Matthias P.; O’Brien, Edward P.; Kramer, Günter & Bukau, Bernd
-
(2017). Split-BioID a conditional proteomics approach to monitor the composition of spatiotemporally defined protein complexes. Nat Commun
Schopp, Isabel Myriam; Amaya Ramirez, Cinthia Claudia; Debeljak, Jerneja; Kreibich, Elisa; Skribbe, Merle; Wild, Klemens & Béthune, Julien
-
(2017). Strigolactone- and Karrikin-Independent SMXL Proteins Are Central Regulators of Phloem Formation. Curr Biol
Wallner, Eva-Sophie; López-Salmerón, Vadir; Belevich, Ilya; Poschet, Gernot; Jung, Ilona; Grünwald, Karin; Sevilem, Iris; Jokitalo, Eija; Hell, Rüdiger; Helariutta, Yrjö; Agustí, Javier; Lebovka, Ivan & Greb, Thomas
-
(2017). Structural basis of HypK regulating N-terminal acetylation by the NatA complex. Nat Commun
Weyer, Felix Alexander; Gumiero, Andrea; Lapouge, Karine; Bange, Gert; Kopp, Jürgen & Sinning, Irmgard
-
(2017). Sulfur availability regulates plant growth via glucose-TOR signaling. Nat Commun
Dong, Yihan; Silbermann, Marleen; Speiser, Anna; Forieri, Ilaria; Linster, Eric; Poschet, Gernot; Allboje Samami, Arman; Wanatabe, Mutsumi; Sticht, Carsten; Teleman, Aurelio A.; Deragon, Jean-Marc; Saito, Kazuki; Hell, Rüdiger & Wirtz, Markus
-
(2017). Telomere Length Determines TERRA and R-Loop Regulation through the Cell Cycle. Cell
Graf, Marco; Bonetti, Diego; Lockhart, Arianna; Serhal, Kamar; Kellner, Vanessa; Maicher, André; Jolivet, Pascale; Teixeira, Maria Teresa & Luke, Brian
-
(2017). Upregulation of SPS100 gene expression by an antisense RNA via a switch of mRNA isoforms with different stabilities. Nucleic Acids Res
Bunina, Daria; Štefl, Martin; Huber, Florian; Khmelinskii, Anton; Meurer, Matthias; Barry, Joseph D.; Kats, Ilia; Kirrmaier, Daniel; Huber, Wolfgang & Knop, Michael
-
(2018). BRI1 controls vascular cell fate in the Arabidopsis root through RLP44 and phytosulfokine signaling. Proc Natl Acad Sci USA
Holzwart, Eleonore; Huerta, Apolonio Ignacio; Glöckner, Nina; Garnelo Gómez, Borja; Wanke, Friederike; Augustin, Sebastian; Askani, Jana Christin; Schürholz, Ann-Kathrin; Harter, Klaus & Wolf, Sebastian
-
(2018). Capsid protein structure, self-assembly, and processing reveal morphogenesis of the marine virophage mavirus. Proc Natl Acad Sci USA
Born, Diana; Reuter, Lukas; Mersdorf, Ulrike; Mueller, Melanie; Fischer, Matthias G.; Meinhart, Anton & Reinstein, Jochen
-
(2018). Clathrin-adaptor ratio and membrane tension regulate the flat-to-curved transition of the clathrin coat during endocytosis. Nat Commun
Bucher, Delia; Frey, Felix; Sochacki, Kem A.; Kummer, Susann; Bergeest, Jan-Philip; Godinez, William J.; Kräusslich, Hans-Georg; Rohr, Karl; Taraska, Justin W.; Schwarz, Ulrich S. & Boulant, Steeve
-
(2018). Identification, Biosynthesis, and Decapping of NAD-Capped RNAs in B. subtilis. Cell Rep
Frindert, Jens; Zhang, Yaqing; Nübel, Gabriele; Kahloon, Masroor; Kolmar, Leonie; Hotz-Wagenblatt, Agnes; Burhenne, Jürgen; Haefeli, Walter E. & Jäschke, Andres
-
(2018). Mapping degradation signals and pathways in a eukaryotic N-terminome. Mol Cell
Kats, Ilia; Khmelinskii, Anton; Kschonsak, Marc; Huber, Florian; Knieß, Robert A.; Bartosik, Anna & Knop, Michael
-
(2018). Neurovascular Communication during CNS Development. Dev Cell
Paredes, Isidora; Himmels, Patricia & Ruiz de Almodóvar, Carmen
-
(2018). Phenotypic memory in Bacillus subtilis links dormancy entry and exit by a spore quantity-quality tradeoff. Nat Commun
Mutlu, Alper; Trauth, Stephanie; Ziesack, Marika; Nagler, Katja; Bergeest, Jan-Philip; Rohr, Karl; Becker, Nils; Höfer, Thomas & Bischofs, Ilka B.
-
(2018). Secretion of Hepatitis C Virus Replication Intermediates Reduces Activation of Toll Like Receptor 3 in Hepatocytes. Gastroenterology
Grünvogel, Oliver; Colasanti, Ombretta; Lee, Ji-Young; Klöss, Volker; Belouzard, Sandrine; Reustle, Anna; Esser-Nobis, Katharina; Hesebeck-Brinckmann, Jasper; Mutz, Pascal; Hoffmann, Katrin; Mehrabi, Arianeb; Koschny, Ronald; Vondran, Florian W.R.; Gotthardt, Daniel; Schnitzler, Paul; Neumann-Haefelin, Christoph; Thimme, Robert; Binder, Marco; Bartenschlager, Ralf; ... & Lohmann, Volker
-
(2018). SHRED Is a Regulatory Cascade that Reprograms Ubr1 Substrate Specificity for Enhanced Protein Quality Control during Stress. Mol Cell
Szoradi, Tamas; Schaeff, Katharina; Garcia-Rivera, Enrique M.; Itzhak, Daniel N.; Schmidt, Rolf M.; Bircham, Peter W.; Leiss, Kevin; Diaz-Miyar, Juan; Chen, Vivian K.; Muzzey, Dale; Borner, Georg H.H. & Schuck, Sebastian
-
(2018). Single event visualization of unconventional secretion of FGF2. J Cell Biol
Dimou, Eleni; Cosentino, Katia; Platonova, Evgenia; Ros, Uris; Sadeghi, Mohsen; Kashyap, Purba; Katsinelos, Taxiarchis; Wegehingel, Sabine; Noé, Frank; García-Sáez, Ana J.; Ewers, Helge & Nickel, Walter
-
(2018). The lncRNA CASC9 and RNA binding protein HNRNPL form a complex and coregulate genes linked to AKT signaling. Hepatology
Klingenberg, Marcel; Groß, Matthias; Goyal, Ashish; Polycarpou‐Schwarz, Maria; Miersch, Thilo; Ernst, Anne‐Sophie; Leupold, Jörg; Patil, Nitin; Warnken, Uwe; Allgayer, Heike; Longerich, Thomas; Schirmacher, Peter; Boutros, Michael & Diederichs, Sven
-
(2018). The ng_ζ1 toxin of the gonococcal epsilon/zeta toxin/antitoxin system drains precursors for cell wall synthesis. Nat Commun
Rocker, Andrea; Peschke, Madeleine; Kittilä, Tiia; Sakson, Roman; Brieke, Clara & Meinhart, Anton
