GSC 249:  The Hartmut Hoffmann-Berling International Graduate School of Molecular and Cellular Biology

• Subject Area: Basic Research in Biology and Medicine
• Term: from 2007 to 2019
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 39338214

• Final Report Year: 2019

Final Report Abstract

The Hartmut Hoffmann-Berling International Graduate School of Molecular & Cellular Biology Heidelberg, renamed to Heidelberg Biosciences International Graduate School (henceforth “HBIGS”) in 2018, was founded in Oct 2007 with the vision to attract the best and brightest doctoral researchers from around the world to pursue doctoral studies at Heidelberg University. Since then, HBIGS has developed into the largest and most visible structured graduate programme for life sciences at Heidelberg University. During the initial funding period, HBIGS implemented an innovative approach to doctoral training, with a strong emphasis on interdisciplinarity, a structured PhD program, shared supervision by thesis advisory committees, a vocational concept, the integration of an MD/PhD program, and the implementation of measures to promote women and scientists with young families. During the second funding period, HBIGS has evolved from a thematically focused graduate school into a graduate school for molecular life science that embraces and serves the entire life science community at Heidelberg University as well as non-university institutions. As such HBIGS has managed more than a dozen national and international graduate programs. HBIGS represents a truly international graduate school with more than 40% international doctoral researchers and more than 80% international applicants. Indicators of academic excellence of the HBIGS student body are an impressive publication record of more than 1,500 peer-reviewed scientific articles authored by our doctoral researchers, a mean time to degree of 4.1 years, a low drop-out rate 7%, a balanced gender distribution, and excellent employment opportunities for graduates.

Publications

• (2010). Components of the Hippo pathway cooperate with Nek2 kinase to regulate centrosome disjunction. Nat Cell Biol
  Mardin BR, Lange C, Baxter JE, Hardy T, Scholz SR, Fry AM, Schiebel E
  (See online at https://doi.org/10.1038/ncb2120)
• (2010). Mutations detected in the SHANK2 synaptic scaffolding gene in autism spectrum disorder and mental retardation. Nat Genet
  Berkel S, Marshall CR, Weiss B, Howe J, Roeth R, Moog U, Endris V, Roberts W, Szatmari P, Pinto D, Bonin M, Riess A, Engels H, Sprengel R, Scherer SW, Rappold GA
  (See online at https://doi.org/10.1038/ng.589)
• (2010). Stimulation of Cell Adhesion at nanostructured Teflon Interfaces. Advanced Materials
  Kruss S, Wolfram T, Martin R, Neubauer S, Kessler H, Spatz JP
  (See online at https://doi.org/10.1002/adma.201003055)
• (2011). Hepatic deficiency in transcriptional cofactor TBL1 promotes liver steatosis and hypertriglyceridemia. Cell Metab
  Kulozik P, Jones A, Mattijssen F, Rose AJ, Reimann A, Strzoda D, Kleinsorg S, Raupp C, Kleinschmidt J, Müller-Decker K, Wahli W, Sticht C, Gretz N, von Loeffelholz C, Stockmann M, Pfeiffer A, Stöhr S, Dallinga-Thie GM, Nawroth PP, Berriel Diaz M, Herzig S
  (See online at https://doi.org/10.1016/j.cmet.2011.02.011)
• (2011). Mapping of Signalling Networks through Synthetic Genetic Interaction Analysis by RNAi. Nature Methods
  Horn T, Sandmann T, Fischer B, Axelsson E, Huber W, Boutros M
  (See online at https://doi.org/10.1038/nmeth.1581)
• (2011). Recruitment and Activation of a Lipid Kinase by Hepatitis C Virus NS5A Is Essential for Integrity of the Membranous Replication Compartment. Cell Host Microbe
  Reiss S, Rebhan I, Backes P, Romero-Brey I, Erfle H, Matula P, Kaderali L, Poenisch M, Blankenburg H, Hiet MS, Longerich T, Diehl S, Ramirez F, Balla T, Rohr K, Kaul A, Bühler S, Pepperkok R, Lengauer T, Albrecht M, Eils R, Schirmacher P, Lohmann V
  (See online at https://doi.org/10.1016/j.chom.2010.12.002)
• (2012). An extended gamma-tubulin ring functions as a stable platform in microtubule nucleation. J Cell Biol
  Erlemann S, Neuner A, Gombos L, Gibeaux R, Anthony C, Schiebel E
  (See online at https://doi.org/10.1083/jcb.201111123)
• (2012). Identification of type I and type II interferon-induced effectors controlling hepatitis C virus replication. Hepatology
  Metz P, Dazert E, Ruggieri A, Mazur J, Kaderali L, Kaul A, Zeuge U, Trippler M, Lohmann V, Binder M, Frese M, Bartenschlager R
  (See online at https://doi.org/10.1002/hep.25908)
• (2012). Rif2 Promotes a Telomere Fold-Back Structure through Rpd3L Recruitment in Budding Yeast. PLoS Genet
  Poschke H, Dees M, Chang M, Amberkar S, Kaderali L, Rothstein R, Luke B
  (See online at https://doi.org/10.1371/journal.pgen.1002960)
• (2012). Site-specific terminal and internal labeling of RNA by poly(A) polymerase tailing and copper-catalyzed or copper-free strainpromoted click chemistry. Nucleic Acids Res
  Winz ML, Samanta A, Benzinger D, Jäschke A
  (See online at https://doi.org/10.1093/nar/gks062)
• (2012). Structure and Dynamics of the ATP-Bound Open Conformation of Hsp70 Chaperones. Mol Cell
  Kityk R, Kopp J, Sinning I, Mayer MP
  (See online at https://doi.org/10.1016/j.molcel.2012.09.023)
• (2012). The cisregulatory code of Hox function in Drosophila. EMBO J
  Sorge S, Ha N, Polychronidou M, Friedrich J, Bezdan D, Kaspar P, Schaefer MH, Ossowski S, Henz SR, Mundorf J, Rätzer J, Papagiannouli F, Lohmann I
  (See online at https://doi.org/10.15252/embj.201593321)
• (2012). Ubiquitin-Dependent Intramembrane Rhomboid Protease Promotes ERAD of Membrane Proteins. Mol Cell
  Fleig L, Bergbold N, Sahasrabudhe P, Geiger B, Kaltak L, Lemberg MK
  (See online at https://doi.org/10.1016/j.molcel.2012.06.008)
• (2013). Analysis of hepatitis C virus resistance to silibinin in vitro and in vivo points to a novel mechanism involving nonstructural protein 4B. Hepatology
  Esser-Nobis K, Romero-Brey I, Ganten TM, Gouttenoire J, Harak C, Klein R, Schemmer P, Binder M, Schnitzler P, Moradpour D, Bartenschlager R, Polyak SJ, Stremmel W, Penin F, Eisenbach C, Lohmann V
  (See online at https://doi.org/10.1002/hep.26260)
• (2013). Detecting endogenous SUMO targets in mammalian cells and tissues. Nat Struct Mol Biol
  Becker J, Barysch SV, Karaca S, Dittner C, Hsiao HH, Berriel Diaz M, Herzig S, Urlaub H, Melchior F
  (See online at https://doi.org/10.1038/nsmb.2526)
• (2013). Posttranscriptional regulation of the trypanosome heat shock response by a zinc finger protein. PLoS Pathog
  Droll D, Minia I, Fadda A, Singh A, Stewart M, Queiroz R, Clayton C
  (See online at https://doi.org/10.1371/journal.ppat.1003286)
• (2013). Telomeric RNA-DNA hybrids affect telomere-length dynamics and senescence. Nat Struct Mol Biol
  Balk B, Maicher A, Dees M, Klermund J, Luke-Glaser S, Bender K, Luke B
  (See online at https://doi.org/10.1038/nsmb.2662)
• (2013). The Lipid Kinase Phosphatidylinositol-4 Kinase III Alpha Regulates the Phosphorylation Status of Hepatitis C Virus NS5A. PLoS Pathog
  Reiss S, Harak C, Romero-Brey I, Radujkovic D, Klein R, Ruggieri A, Rebhan I, Bartenschlager R, Lohmann V
  (See online at https://doi.org/10.1371/journal.ppat.1003359)
• (2013). Tunable Substrates Unveil Chemical Complementation of a Genetic Cell Migration Defect. Adv Healthc Mater
  Hellmann JK, Perschmann N, Spatz JP, Frischknecht F
  (See online at https://doi.org/10.1002/adhm.201200426)
• (2014). A mechanistic framework for noncell autonomous stem cell induction in Arabidopsis. Proc Natl Acad Sci USA
  Daum G, Medzihradszky A, Suzaki T, Lohmann JU
  (See online at https://doi.org/10.1073/pnas.1406446111)
• (2014). A TOGL domain specifically targets yeast CLASP to kinetochores to stabilize kinetochore microtubules. J Cell Biol
  Funk C, Schmeiser V, Ortiz J, Lechner J
  (See online at https://doi.org/10.1083/jcb.201310018)
• (2014). A vaccine targeting mutant IDH1 induces antitumour immunity. Nature
  Schumacher T, Bunse L, Pusch S, Sahm F, Wiestler B, Quandt J, Menn O, Osswald M, Oezen I, Ott M, Keil M, Balß J, Rauschenbach K, Grabowska AK, Vogler I, Diekmann J, Trautwein N, Eichmüller SB, ..., Wick W, Platten M
  (See online at https://doi.org/10.1038/nature13387)
• (2014). Cyclosporin A inhibits Hepatitis B and Hepatitis D Virus entry by Cyclophilin-independent interference with the NTCP receptor. J Hepatol
  Nkongolo S, Ni Y, Lempp FA, Kaufman C, Lindner T, Esser-Nobis K, Lohmann V, Mier W, Mehrle S, Urban S
  (See online at https://doi.org/10.1016/j.jhep.2013.11.022)
• (2014). Cytosolic peroxidases protect the lysosome of bloodstream african trypanosomes from ironmediated membrane damage. PLoS Pathog
  Hiller C, Nissen A, Benítez D, Comini MA, Krauth-Siegel RL
  (See online at https://doi.org/10.1371/journal.ppat.1004075)
• (2014). E-CRISP: fast CRISPR target site identification. Nat Methods
  Heigwer F, Kerr G, Boutros M
  (See online at https://doi.org/10.1038/nmeth.2812)
• (2014). Elements in nucleotide sensing and hydrolysis of the AAA+ disaggregation machine ClpB: a structurebased mechanistic dissection of a molecular motor. Acta Crystallogr D Biol Crystallogr
  Zeymer C, Barends TRM, Werbeck ND, Schlichting I, Reinstein J
  (See online at https://doi.org/10.1107/S1399004713030629)
• (2014). Male-female communication triggers calcium signatures during fertilization in Arabidopsis. Nat Commun
  Denninger P, Bleckmann A, Lausser A, Vogler F, Ott T, Ehrhardt DW, Frommer WB, Sprunck S, Dresselhaus T, Grossmann G
  (See online at https://doi.org/10.1038/ncomms5645)
• (2014). RGS5 promotes arterial growth during arteriogenesis. EMBO Mol Med
  Arnold C, Feldner A, Pfisterer L, Hödebeck M, Troidl K, Genové G, Wieland T, Hecker M, Korff T
  (See online at https://doi.org/10.15252/emmm.201403864)
• (2014). RNA Specificity and Regulation of Catalysis in the Eukaryotic Polynucleotide Kinase Clp1. Mol Cell
  Dikfidan A, Loll B, Zeymer C, Magler I, Clausen T, Meinhart A
  (See online at https://doi.org/10.1016/j.molcel.2014.04.005)
• (2014). Signal peptide peptidase functions in ERAD to cleave the unfolded protein response regulator XBP1u. EMBO J
  Chen CY, Malchus NS, Hehn B, Stelzer W, Avci D, Langosch D, Lemberg MK
  (See online at https://doi.org/10.15252/embj.201488208)
• (2014). Structure of the complete bacterial SRP Alu domain. Nucleic Acids Res
  Kempf G, Wild K, Sinning I
  (See online at https://doi.org/10.1093/nar/gku883)
• (2014). The E3 Ligase CUL3/RDX Controls Centromere Maintenance by Ubiquitylating and Stabilizing CENP-A in a CAL1-Dependent Manner. Dev Cell
  Bade D, Pauleau AL, Wendler A, Erhardt S
  (See online at https://doi.org/10.1016/j.devcel.2014.01.031)
• (2014). The Yeast ER- Intramembrane Protease Ypf1 Refines Nutrient Sensing by Regulating Transporter Abundance. Mol Cell
  Avci D, Fuchs S, Schrul B, Fukumori A, Breker M, Frumkin I, Chen CY, Biniossek ML, Kremmer E, Schilling O, Steiner H, Schuldiner M, Lemberg MK
  (See online at https://doi.org/10.1016/j.molcel.2014.10.012)
• (2014). Translational Regulation of Specific mRNAs Controls Feedback Inhibition and Survival during Macrophage Activation. PLoS Genet
  Schott J, Reitter S, Philipp J, Haneke K, Schäfer H, Stoecklin G
  (See online at https://doi.org/10.1371/journal.pgen.1004368)
• 2014). Highly efficient CRISPR/Cas9-mediated knock-in in zebrafish by homology-independent DNA repair. Genome Res
  Auer TO, Duroure K, De Cian A, Concordet JP, Del Bene F
  (See online at https://doi.org/10.1101/gr.161638.113)
• 2014). Quantitative determination of decitabine incorporation into DNA and its effect on mutation rates in human cancer cells. Nucleic Acids Res
  Öz S, Raddatz G, Rius M, Blagitko-Dorfs N, Lübbert M, Maercker C, Lyko F
  (See online at https://doi.org/10.1093/nar/gku775)
• (2015). A Functional Role for VEGFR1 Expressed in Peripheral Sensory Neurons in Cancer Pain. Cancer Cell
  Selvaraj D, Gangadharan V, Michalski CW, Kurejova M, Stösser S, Srivastava K, Schweizerhof M, Waltenberger J, Ferrara N, Heppenstall P, Shibuya M, Augustin HG, Kuner R
  (See online at https://doi.org/10.1016/j.ccell.2015.04.017)
• (2015). Alleviation of off-target effects from vector-encoded shRNAs via codelivered RNA decoys. Proc Natl Acad Sci USA,
  Mockenhaupt S, Grosse S, Rupp D, Bartenschlager R, Grimm D
  (See online at https://doi.org/10.1073/pnas.1510476112)
• (2015). Downregulation of N-terminal acetylation triggers ABA-mediated drought responses in Arabidopsis. Nat Commun
  Linster E, Stephan I, Bienvenut WV, Maple-Grødem J, Myklebust LM, Huber M, Reichelt M, Sticht C, Geir Møller S, Meinnel T, Arnesen T, Giglione C, Hell R, Wirtz M
  (See online at https://doi.org/10.1038/ncomms8640)
• (2015). Evidence that hepatitis B virus replication in mouse cells is limited by the lack of a host cell dependency factor. J Hepatol
  Lempp FA, Mutz P, Lipps C, Wirth D, Bartenschlager R, Urban S
  (See online at https://doi.org/10.1016/j.jhep.2015.10.030)
• (2015). Identification and functional characterization of rare SHANK2 variants in schizophrenia. Mol Psychiatry
  Peykov S, Berkel S, Schoen M, Weiss K, Degenhardt F, Strohmaier J, Weiss B, Proepper C, Schratt G, Nöthen MM, Boeckers TM, Rietschel M, Rappold GA
  (See online at https://doi.org/10.1038/mp.2014.172)
• (2015). Intramembrane protease PARL defines a negative regulator of PINK1- and PARK2/Parkin-dependent mitophagy. Autophagy
  Meissner C, Lorenz H, Hehn B, Lemberg MK
  (See online at https://doi.org/10.1080/15548627.2015.1063763)
• (2015). Nanoscale control of surface immobilized BMP-2: toward a quantitative assessment of BMP-mediated signaling events. Nano Lett
  Schwab EH, Pohl TL, Haraszti T, Schwaerzer GK, Hiepen C, Spatz JP, Knaus P, Cavalcanti-Adam EA
  (See online at https://doi.org/10.1021/acs.nanolett.5b00315)
• (2015). Operon structure and cotranslational subunit association direct protein assembly in bacteria. Science
  Shieh YW, Minguez P, Bork P, Auburger JJ, Guilbride DL, Kramer G, Bukau B
  (See online at https://doi.org/10.1126/science.aac8171)
• (2015). Regional Cell-Specific Transcriptome Mapping Reveals Regulatory Complexity in the Adult Drosophila Midgut. Cell Rep
  Dutta D, Dobson AJ, Houtz PL, Gläßer C, Revah J, Korzelius J, Patel PH, Edgar BA, Buchon N
  (See online at https://doi.org/10.1016/j.celrep.2015.06.009)
• (2015). Somatic CRISPR/Cas9-mediated tumour suppressor disruption enables versatile brain tumour modelling. Nat Commun
  Zuckermann M, Hovestadt V, Knobbe-Thomsen CB, Zapatka M, Northcott PA, Schramm K, Belic J, Jones DT, Tschida B, Moriarity B, Largaespada D, Roussel MF, Korshunov A, Reifenberger G, Pfister SM, Lichter P, Kawauchi D, Gronych J
  (See online at https://doi.org/10.1038/ncomms8391)
• (2015). Sox2, Tlx, Gli3 and Her9 converge on Rx2 to define retinal stem cells in vivo. EMBO J
  Reinhardt R, Centanin L, Tavhelidse T, Inoue D, Wittbrodt B, Concordet JP, Martinez- Morales JR, Wittbrodt J
  (See online at https://doi.org/10.15252/embj.201490706)
• (2015). Structural basis for assembly and function of the Nup82 complex in the nuclear pore scaffold. J Cell Biol
  Gaik M, Flemming D, von Appen A, Kastritis P, Mücke N, Fischer J, Stelter P, Ori A, Bui KH, Baßler J, Barbar E, Beck M, Hurt E
  (See online at https://doi.org/10.1083/jcb.201411003)
• (2015). The inner workings of the hydrazine synthase multiprotein complex. Nature
  Dietl A, Ferousi C, Maalcke WJ, Menzel A, de Vries S, Keltjens JT, Jetten MS, Kartal B, Barends TR
  (See online at https://doi.org/10.1038/nature15517)
• (2015). The serine protease inhibitor Serpin A3N attenuates neuropathic pain by inhibiting T cell-derived leukocyte elastase. Nat Med
  Vicuña L, Strochlic DE, Latremoliere A, Bali KK, Simonetti M, Husainie D, Prokosch S, Riva P, Griffin RS, Njoo C, Gehrig S, Mall MA, Arnold B, Devor M, Woolf CJ, Liberles SD, Costigan M, Kuner R
  (See online at https://doi.org/10.1038/nm.3852)
• (2015). Transcriptional refractoriness is dependent on core promoter architecture. Nat Commun
  Cesbron F, Oehler M, Ha N, Sancar G, Brunner M
  (See online at https://doi.org/10.1038/ncomms7753)
• (2015). X-domain of peptide synthetases recruits oxygenases crucial for glycopeptide biosynthesis. Nature
  Haslinger K, Peschke M, Brieke C, Maximowitsch E, Cryle MJ
  (See online at https://doi.org/10.1038/nature14141)
• 2015). A Time-Calibrated Road Map of Brassicaceae Species Radiation and Evolutionary History. Plant Cell
  Hohmann N, Wolf EM, Lysak MA, Koch MA
  (See online at https://doi.org/10.1105/tpc.15.00482)
• Compartment-specific aggregases direct distinct nuclear and cytoplasmic aggregate deposition. EMBO J
  Miller SB, Ho CT, Winkler J, Khokhrina M, Neuner A, Mohamed MY, Guilbride DL, Richter K, Lisby M, Schiebel E, Mogk A, Bukau B
  (See online at https://doi.org/10.15252/embj.201489524)
• (2016). A FRET-based study reveals site-specific regulation of spindle position checkpoint proteins at yeast centrosomes. Elife
  Gryaznova Y, Koca Caydasi A, Malengo G, Sourjik V, Pereira G
  (See online at https://doi.org/10.7554/eLife.14029)
• (2016). Acetylation-Dependent Control of Global Poly(A) RNA Degradation by CBP/p300 and HDAC1/2. Mol Cell
  Sharma S, Poetz F, Bruer M, Ly-Hartig TBN, Schott J, Séraphin B, Stoecklin G
  (See online at https://doi.org/10.1016/j.molcel.2016.08.030)
• (2016). Alternative splicing affects the subcellular localization of Drosha. Nucleic Acids Res
  Link S, Grund SE, Diederichs S
  (See online at https://doi.org/10.1093/nar/gkw400)
• (2016). Architecture of the 90S pre-ribosome: a structural view on the birth of the eukaryotic ribosome. Cell
  Kornprobst M, Turk M, Kellner N, Cheng J, Flemming D, Kos-Braun I, Kos M, Thoms M, Berninghausen O, Beckmann R, Hurt E
  (See online at https://doi.org/10.1016/j.cell.2016.06.014)
• (2016). Blue light-induced LOV domain dimerization enhances the affinity of Aureochrome 1a for its target DNA sequence. Elife
  Heintz U, Schlichting I
  (See online at https://doi.org/10.7554/eLife.11860)
• (2016). Global profiling of SRP interaction with nascent polypeptides. Nature
  Schibich D, Gloge F, Pöhner I, Björkholm P, Wade RC, von Heijne G, Bukau B, Kramer G
  (See online at https://doi.org/10.1038/nature19070)
• (2016). New Structural Data Reveal the Motion of Carrier Proteins in Nonribosomal Peptide Synthesis. Angew Chem Int Ed Engl
  Kittilä T, Mollo A, Charkoudian LK, Cryle MJ
  (See online at https://doi.org/10.1002/anie.201602614)
• (2016). Progress of endocytic CHRN to autophagic degradation is regulated by RAB5-GTPase and T145 phosphorylation of SH3GLB1 at mouse neuromuscular junctions in vivo. Autophagy
  Wild F, Khan MM, Straka T, Rudolf R
  (See online at https://doi.org/10.1080/15548627.2016.1234564)
• (2016). Protein Abundance Control by Non-coding Antisense Transcription. Cell Rep
  Huber F, Bunina D, Gupta I, Khmelinskii A, Meurer M, Theer P, Steinmetz LM, Knop M
  (See online at https://doi.org/10.1016/j.celrep.2016.05.043)
• (2016). Regulation of the P450 oxygenation cascade involved in glycopeptide antibiotic biosynthesis. J Am Chem Soc
  Peschke M, Haslinger K, Brieke C, Reinstein J, Cryle MJ
  (See online at https://doi.org/10.1021/jacs.6b00307)
• (2016). Retinoic acid catabolizing enzyme CYP26C1 is a genetic modifier in SHOX deficiency. EMBO Mol Med
  Montalbano A, Juergensen L, Roeth R, Weiss B, Fukami M, Fricke-Otto S, Binder G, Ogata T, Decker E, Nuernberg G, Hassel D, Rappold GA
  (See online at https://doi.org/10.15252/emmm.201606623)
• (2016). Sensory input attenuation allows predictive sexual response in yeast. Nat Commun
  Banderas A, Koltai M, Anders A, Sourjik V
  (See online at https://doi.org/10.1038/ncomms12590)
• (2016). Stimulated Emission Depletion Nanoscopy Reveals Time-Course of Human Immunodeficiency Virus Proteolytic Maturation. ACS Nano
  Hanne J, Göttfert F, Schimer J, Anders-Össwein M, Konvalinka J, Engelhardt J, Müller B, Hell SW, Kräusslich H-G
  (See online at https://doi.org/10.1021/acsnano.6b03850)
• (2016). Structures of human SRP72 complexes provide insights into SRP RNA remodeling and ribosome interaction. Nucleic Acids Res
  Becker MM, Lapouge K, Segnitz B, Wild K, Sinning I
  (See online at https://doi.org/10.1093/nar/gkw1124)
• (2016). Sugar Influx Sensing by the Phosphotransferase System of Escherichia coli. PLoS Biol
  Somavanshi R, Ghosh B, Sourjik V
  (See online at https://doi.org/10.1371/journal.pbio.2000074)
• (2016). SuReSim: simulating localization microscopy experiments from ground truth models. Nat Methods
  Venkataramani V, Herrmannsdörfer F, Heilemann M, Kuner T
  (See online at https://doi.org/10.1038/NMETH.3775)
• (2016). TALEN/CRISPR-mediated engineering of a promoterless anti-viral RNAi hairpin into an endogenous miRNA locus. Nucleic Acids Res
  Senis E, Mockenhaupt S, Rupp D, Bauer T, Paramasivam N, Knapp B, Gronych J, Grosse S, Windisch MP, Schmidt F, Theis FJ, Eils R, Lichter P, Schlesner M, Bartenschlager R, Grimm D
  (See online at https://doi.org/10.1093/nar/gkw805)
• (2016). The Crystal Structure of RosB: Insights into the Reaction Mechanism of the First Member of a Family of Flavodoxin-like Enzymes. Angew Chem Int Ed Engl
  Konjik V, Brünle S, Demmer U, Vanselow A, Sandhoff R, Ermler U, Mack M
  (See online at https://doi.org/10.1002/anie.201610292)
• (2016). The RanBP2/RanGAP1*SUMO1/Ubc9 SUMO E3 ligase is a disassembly machine for Crm1- dependent nuclear export complexes. Nat Commun
  Ritterhoff T, Das H, Hofhaus G, Schröder RR, Flotho A, Melchior F
  (See online at https://doi.org/10.1038/ncomms11482)
• (2016). Transient RNA-DNA Hybrids Are Required for Efficient Double- Strand Break Repair. Cell
  Ohle C, Tesorero R, Schermann G, Dobrev N, Sinning I, Fischer T
  (See online at https://doi.org/10.1016/j.cell.2016.10.001)
• (2017). Glutaredoxin catalysis requires two distinct glutathione interaction sites. Nat Commun
  Begas P, Liedgens L, Moseler A, Meyer AJ, Deponte M
  (See online at https://doi.org/10.1038/ncomms14835)
• (2017). Heteromeric channels formed by TRPC1, TRPC4 and TRPC5 define hippocampal synaptic transmission and working memory. EMBO J
  Bröker-Lai J, Kollewe A, Schindeldecker B, Pohle J, Nguyen Chi V, Mathar I, Guzman R, Schwarz Y, Lai A, Weißgerber P, Schwegler H, Dietrich A, Both M, Sprengel R, Draguhn A, Köhr G, Fakler B, Flockerzi V, Bruns D, Freichel M
  (See online at https://doi.org/10.15252/embj.201696369)
• (2017). Human phosphatase CDC14A regulates actin organization through dephosphorylation of epithelial protein lost in neoplasm. Proc Natl Acad Sci USA
  Chen NP, Uddin B, Hardt R, Ding W, Panic M, Lucibello I, Kammerer P, Ruppert T, Schiebel E
  (See online at https://doi.org/10.1073/pnas.1619356114)
• (2017). Induction of Chromosome Instability by Activation of Yes Associated Protein and Forkhead box M1 in Liver Cancer. Gastroenterology
  Weiler SM, Pinna F, Wolf T, Lutz T, Geldiyev A, Sticht C, Knaub M, Thomann S, Bissinger M, Wan S, Rössler S, Becker D, Gretz N, Lang H, Bergmann F, Ustiyan V, Kalin TV, Singer S, Lee JS, Marquardt JU, Schirmacher P, Kalinichenko VV, Breuhahn K
  (See online at https://doi.org/10.1053/j.gastro.2017.02.018)
• (2017). Motor neurons control blood vessel patterning in the developing spinal cord. Nat Commun
  Himmels P, Paredes I, Adler H, Karakatsani A, Luck R, Marti HH, Ermakova O, Rempel E, Stoeckli ET, Ruiz de Almodóvar C
  (See online at https://doi.org/10.1038/ncomms14583)
• (2017). Neural stem cells induce the formation of their physical niche during organogenesis. Elife
  Seleit A, Krämer I, Riebesehl BF, Ambrosio EM, Stolper JS, Lischik CQ, Dross N, Centanin L
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• (2017). Phosphorylation-Dependent Feedback Inhibition of RIG-I by DAPK1 Identified by Kinome-wide siena Screening. Mol Cell
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