Specification and dynamic interactions of arterial progenitor cells (A10)

• Subject Area: Cell Biology
• Term: since 2018
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 386797833

Arteries are essential for organ growth, maintenance and repair. Yet, the key cellular and molecular mechanisms that govern artery formation remain incompletely understood. Here, using mouse genetics, advanced imaging, single-cell transcriptomics, and in vitro assays, we will address how intercellular and intracellular signaling platforms in endothelial cells control arterial fate specification, arteriovenous segregation, and other aspects of organ-specific vascular growth and patterning.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1348: Dynamic cellular interfaces: formation and function
• Applicant Institution: Universität Münster
• Project Heads: Professor Dr. Ralf H. Adams; Dr. Mara E. Pitulescu