Project Details
Projekt
Regulation of plasma membrane supramolecular functional units by late endosomal sorting and transport (A11)
Subject Area
Cell Biology
Term
since 2018
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 386797833
The endothelial plasma membrane is dynamically remodeled through demand-driven exocytosis of endothelial-specific storage compartments, the Weibel-Palade bodies (WPB). We study how cargo is delivered from endolysosomes to WPB, how cell stress alters this poorly characterized pathway, and analyze the impact on PM hubs. We focus on endolysosomal cholesterol balance, and thus also use and further develop novel cholesterol analogs (CHIMs) as chemical tools to investigate cholesterol-related dynamic membrane processes.
DFG Programme
Collaborative Research Centres
Applicant Institution
Universität Münster
Project Heads
Professor Dr. Frank Glorius, since 1/2021; Professorin Dr. Ursula Rescher
