Novel luminophors with aggregation induced emission properties for protein recognition (A10)

• Subject Area: Biological and Biomimetic Chemistry
• Term: from 2018 to 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 229838028

Project A10 deals with the synthesis, characterisation and application of novel luminophores with aggregation-induced emission for the recognition of proteins. To this end novel artificial amino-acids will be synthesized and used in a peptide library. Upon binding to a protein a fluorescence signal is expected due to a restriction of intramolecular rotation of the luminophores. This approach represents a completely new tool for the identification of protein ligands. Furthermore we aim for the synthesis of multivalent platforms with AIE properties in collaboration with groups from the CRC 1093 for the recognition of protein surfaces, pores and binding pockets.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1093: Supramolecular Chemistry on Proteins
• Applicant Institution: Universität Duisburg-Essen
• Project Head: Professor Dr. Jens Voskuhl