Generation, molecular characteristics and effector mechanisms of CSF2+ T cells in GvHD (B03)

• Subject Area: Immunology ; Gastroenterology ; Clinical Immunology and Allergology ; Medical Microbiology and Mycology, Hygiene, Molecular Infection Biology
• Term: since 2018
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 324392634

Based on our preliminary work we hypothesize that distinct microbial signatures foster a subtle immunological milieu shift thereby promoting CSF2+ T cell-mediated GvHD. To test this systematically, we link immune, microbial and clinical profiles of CSF2-driven intestinal pathology in preclinical models. Moreover, we perform in depth characterizations of blood and gut CSF-2+ T cells in ASCT patients to explore the mechanisms of T cell differentiation. Lastly, our microbiome analysis seeks to identify drivers of CSF2 in ASCT patients. Overall, we aim to identify key mechanisms underlying CSF2+ T cell driven GvHD.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 221: Modulation of graft-versus-host and graft-versus-leukemia immune responses after allogeneic stem cell transplantation
• Applicant Institution: Universität Regensburg
• Project Heads: Professor Dr. Kai Hildner; Professorin Dr. Christiane Krystelle Nganou Makamdop, since 1/2026